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Molecules 2016, 21(8), 1038;

Chemo-Enzymatic Synthesis of Oligoglycerol Derivatives

Department of Chemistry, University of Delhi, Delhi 110007, India
Université de Technologie de Compiègne (UTC), CS 60319, Compiègne Cedex 60203, France
Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, Berlin 14195, Germany
Authors to whom correspondence should be addressed.
Academic Editor: Davide Ravelli
Received: 20 July 2016 / Revised: 4 August 2016 / Accepted: 5 August 2016 / Published: 9 August 2016
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A cleaner and greener method has been developed and used to synthesize 14 different functionalized oligomer derivatives of glycerol in moderate 29%–39% yields over three steps. After successive regioselective enzymatic acylation of the primary hydroxyl groups, etherification or esterification of the secondary hydroxyl groups and chemoselective enzymatic saponification, the target compounds can efficiently be used as versatile building blocks in organic and supramolecular chemistry. View Full-Text
Keywords: glycerol oligomers; Novozym 435; chemo-enzymatic; regioselectivity; building blocks glycerol oligomers; Novozym 435; chemo-enzymatic; regioselectivity; building blocks

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Singh, A.K.; Nguyen, R.; Galy, N.; Haag, R.; Sharma, S.K.; Len, C. Chemo-Enzymatic Synthesis of Oligoglycerol Derivatives. Molecules 2016, 21, 1038.

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