Next Article in Journal
Gingerol Synergizes the Cytotoxic Effects of Doxorubicin against Liver Cancer Cells and Protects from Its Vascular Toxicity
Next Article in Special Issue
Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects
Previous Article in Journal
Cytotoxic Alkaloids from the Stem of Xylopia laevigata
Previous Article in Special Issue
Coffee Silverskin Extract Protects against Accelerated Aging Caused by Oxidative Agents
 
Search for Articles:
Title / Keyword
Author / Affiliation
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
Journals
Molecules
Volume 21
Issue 7
10.3390/molecules21070899
molecules-logo
Submit to this Journal Review for this Journal Edit a Special Issue
► Article Menu

Article Menu

share announcement question_answer thumb_up
...
textsms
...
Article

Gallic Acid Promotes Wound Healing in Normal and Hyperglucidic Conditions

by
Dong Joo Yang
1,2,†,
Sang Hyun Moh
3,†,
Dong Hwee Son
1,4,
Seunghoon You
1,
Ann W. Kinyua
1,2,
Chang Mann Ko
1,
Miyoung Song
3,
Jinhee Yeo
5,
Yun-Hee Choi
3,* and
Ki Woo Kim
1,2,*
1
Department of Pharmacology, Wonju College of Medicine, Yonsei University, Wonju 26426, Korea
2
Department of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Korea
3
Anti-Aging Research Institute of BIO-FD & C Co. Ltd., Incheon 21990, Korea
4
Department of Wellness & Healthy Aging, Wonju College of Medicine, Yonsei University, Wonju 26426, Korea
5
Jeongseon Agricultural Extension Center, Jeongseon 26103, Korea
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Academic Editor: Pedro Mena
Molecules 2016, 21(7), 899; https://doi.org/10.3390/molecules21070899
Received: 19 March 2016 / Revised: 28 June 2016 / Accepted: 1 July 2016 / Published: 8 July 2016
(This article belongs to the Special Issue New Frontiers on the Metabolism, Bioavailability and Health Effects of Phenolic Compounds)
View Full-Text Download PDF
Browse Figures

Abstract

Skin is the outermost layer of the human body that is constantly exposed to environmental stressors, such as UV radiation and toxic chemicals, and is susceptible to mechanical wounding and injury. The ability of the skin to repair injuries is paramount for survival and it is disrupted in a spectrum of disorders leading to skin pathologies. Diabetic patients often suffer from chronic, impaired wound healing, which facilitate bacterial infections and necessitate amputation. Here, we studied the effects of gallic acid (GA, 3,4,5-trihydroxybenzoic acid; a plant-derived polyphenolic compound) on would healing in normal and hyperglucidic conditions, to mimic diabetes, in human keratinocytes and fibroblasts. Our study reveals that GA is a potential antioxidant that directly upregulates the expression of antioxidant genes. In addition, GA accelerated cell migration of keratinocytes and fibroblasts in both normal and hyperglucidic conditions. Further, GA treatment activated factors known to be hallmarks of wound healing, such as focal adhesion kinases (FAK), c-Jun N-terminal kinases (JNK), and extracellular signal-regulated kinases (Erk), underpinning the beneficial role of GA in wound repair. Therefore, our results demonstrate that GA might be a viable wound healing agent and a potential intervention to treat wounds resulting from metabolic complications. View Full-Text
Keywords: gallic acid; wound healing; cell migration; hyperglucidic condition gallic acid; wound healing; cell migration; hyperglucidic condition
►▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
SciFeed

Share and Cite

MDPI and ACS Style

Yang, D.J.; Moh, S.H.; Son, D.H.; You, S.; Kinyua, A.W.; Ko, C.M.; Song, M.; Yeo, J.; Choi, Y.-H.; Kim, K.W. Gallic Acid Promotes Wound Healing in Normal and Hyperglucidic Conditions. Molecules 2016, 21, 899. https://doi.org/10.3390/molecules21070899

AMA Style

Yang DJ, Moh SH, Son DH, You S, Kinyua AW, Ko CM, Song M, Yeo J, Choi Y-H, Kim KW. Gallic Acid Promotes Wound Healing in Normal and Hyperglucidic Conditions. Molecules. 2016; 21(7):899. https://doi.org/10.3390/molecules21070899

Chicago/Turabian Style

Yang, Dong J., Sang H. Moh, Dong H. Son, Seunghoon You, Ann W. Kinyua, Chang M. Ko, Miyoung Song, Jinhee Yeo, Yun-Hee Choi, and Ki W. Kim. 2016. "Gallic Acid Promotes Wound Healing in Normal and Hyperglucidic Conditions" Molecules 21, no. 7: 899. https://doi.org/10.3390/molecules21070899

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Map by Country/Region

1
Back to TopTop