Next Article in Journal
Dual Behavior of Iodine Species in Condensation of Anilines and Vinyl Ethers Affording 2-Methylquinolines
Next Article in Special Issue
Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1)
Previous Article in Journal
A Metagenomic Advance for the Cloning and Characterization of a Cellulase from Red Rice Crop Residues
Previous Article in Special Issue
Capsaicin Synthesis Requires in Situ Phenylalanine and Valine Formation in in Vitro Maintained Placentas from Capsicum chinense
Open AccessReview

The Effect of Capsaicin on Salivary Gland Dysfunction

Department of Physiology, School of Dentistry, Seoul National University and Dental Research Institute, Seoul 110-749, Korea
Author to whom correspondence should be addressed.
Academic Editor: Pin Ju Chueh
Molecules 2016, 21(7), 835;
Received: 25 May 2016 / Revised: 20 June 2016 / Accepted: 22 June 2016 / Published: 25 June 2016
(This article belongs to the Special Issue Capsaicin)
Capsaicin (trans-8-methyl-N-vanilyl-6-nonenamide) is a unique alkaloid isolated from hot chili peppers of the capsicum family. Capsaicin is an agonist of transient receptor potential vanilloid subtype 1 (TRPV1), which is expressed in nociceptive sensory neurons and a range of secretory epithelia, including salivary glands. Capsaicin has analgesic and anti-inflammatory properties in sensory neurons. Recently, increasing evidence has indicated that capsaicin also affects saliva secretion and inflammation in salivary glands. Applying capsaicin increases salivary secretion in human and animal models. Capsaicin appears to increase salivation mainly by modulating the paracellular pathway in salivary glands. Capsaicin activates TRPV1, which modulates the permeability of tight junctions (TJ) by regulating the expression and function of putative intercellular adhesion molecules in an ERK (extracelluar signal-regulated kinase) -dependent manner. Capsaicin also improved dysfunction in transplanted salivary glands. Aside from the secretory effects of capsaicin, it has anti-inflammatory effects in salivary glands. The anti-inflammatory effect of capsaicin is, however, not mediated by TRPV1, but by inhibition of the NF-κB pathway. In conclusion, capsaicin might be a potential drug for alleviating dry mouth symptoms and inflammation of salivary glands. View Full-Text
Keywords: Capsaicin; Salivary glands; TRPV1; NF-κB Capsaicin; Salivary glands; TRPV1; NF-κB
Show Figures

Figure 1

MDPI and ACS Style

Shin, Y.-H.; Kim, J.M.; Park, K. The Effect of Capsaicin on Salivary Gland Dysfunction. Molecules 2016, 21, 835.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop