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Molecules 2016, 21(5), 577;

New Aspects in the Formulation of Drugs Based on Three Case Studies

Thermische Verfahrenstechnik, Zentrum für Ingenieurwissenschaften, Martin-Luther-Universität Halle-Wittenberg, Zentrum für Ingenieurwissenschaften, Halle 06099, Germany
Author to whom correspondence should be addressed.
Academic Editor: Sohrab Rohani
Received: 7 March 2016 / Revised: 20 April 2016 / Accepted: 22 April 2016 / Published: 30 April 2016
(This article belongs to the Special Issue Crystallization of Pharmaceuticals)
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The improvement of pharmaceutical dosage forms, such as tablets, towards drug delivery control and cost efficiency is of great importance in formulation technologies. Here, three examples: in situ coating, freeze casting and protein-based biocomposites are presented that address the above mentioned issues and contribute to further developments in formulation technologies. The in situ coating increases the economic efficiency by saving process steps in comparison to a conventional tableting process and provides a crystalline coating for a tailorable drug delivery rate. The freeze casting allows the control over the surface area of a drug delivery system (DDS) by providing different numbers and sizes of pores, which in conjunction with adequate additives offer an efficient instrument for drug delivery control, especially by accelerating the dissolution effect. Protein-based biocomposites are attractive materials for biomedical and pharmaceutical applications that can be applied as a polymeric DDS. They inherently combine degradability in vivo and in vitro, show a good biocompatibility, offer sites of adhesion for cells and may additionally be used to release embedded bioactive molecules. Here, a new approach regarding the incorporation of crystalline active pharmaceutical ingredients (API) into a protein matrix in one process step is presented. All three presented techniques mark decisive progress towards tailor-made drug delivery systems with respect to function, economic efficiency and the generation of additional values. View Full-Text
Keywords: in situ coating; freeze casting; biocomposites; proteins; controlled release in situ coating; freeze casting; biocomposites; proteins; controlled release

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Frohberg, P.; Nguyen, T.N.P.; Ulrich, J. New Aspects in the Formulation of Drugs Based on Three Case Studies. Molecules 2016, 21, 577.

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