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Molecules 2016, 21(3), 274;

Sesquiterpenoids from Chinese Agarwood Induced by Artificial Holing

1,2,* and 1,2,*
Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China
Hainan Engineering Research Center of Agarwood, Haikou 571101, Hainan, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 22 January 2016 / Revised: 22 February 2016 / Accepted: 23 February 2016 / Published: 26 February 2016
(This article belongs to the Collection Bioactive Compounds)
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Two new sesquiterpenoids, 3-oxo-7-hydroxylholosericin A (1) and 1,5;8,12-diepoxy-guaia-12-one (2), together with seven known sesquiterpenoids 3–9, were isolated from Chinese agarwood induced by artificial holing originating from Aquilaria sinensis (Lour.) Gilg. Their structures were identified by spectroscopic techniques (UV, IR, 1D and 2D NMR) and MS analyses. The absolute configuration of compound 1 was determined by comparison of its measured CD curve with that of calculated data for 1 and ent-1. The NMR data of 3 were reported in this study for the first time. Compounds 1, 2, 4–6, together with the EtOAc extract showed moderate inhibitory activities against acetylcholinesterase, and compounds 4–6, 8 exhibited antibacterial activities against Staphylococcus aureus or Ralstonia solanacearum. View Full-Text
Keywords: sesquiterpenoid; Chinese agarwood induced by artificial holing; Aquilaria sinensis; AChE inhibition activity; antibacterial activity sesquiterpenoid; Chinese agarwood induced by artificial holing; Aquilaria sinensis; AChE inhibition activity; antibacterial activity

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Li, W.; Liao, G.; Dong, W.-H.; Kong, F.-D.; Wang, P.; Wang, H.; Mei, W.-L.; Dai, H.-F. Sesquiterpenoids from Chinese Agarwood Induced by Artificial Holing. Molecules 2016, 21, 274.

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