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Erratum: Pferschy-Wenzig, E.-M.; et al. Does a Graphical Abstract Bring More Visibility to Your Paper? Molecules 2016, 21, 1247
Open AccessArticle

Synthesis and Antitumor Activity of 5-Bromo-7-azaindolin-2-one Derivatives Containing a 2,4-Dimethyl-1H-pyrrole-3-carboxamide Moiety

by Jun Zhang 1,2,†, Weiyi Shen 2,†, Xiaoning Li 1, Yun Chai 1,*, Senjun Li 2, Kai Lv 1, Huiyuan Guo 1 and Mingliang Liu 1,*
1
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2
Zhejiang Starry Pharmaceutical Co. Ltd., Xianju 317300, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Maria Emília de Sousa
Molecules 2016, 21(12), 1674; https://doi.org/10.3390/molecules21121674
Received: 11 November 2016 / Revised: 28 November 2016 / Accepted: 30 November 2016 / Published: 6 December 2016
(This article belongs to the Section Medicinal Chemistry)
We report herein the design and synthesis of a series of novel 5-bromo-7-azaindolin-2-one derivatives containing a 2,4-dimethyl-1H-pyrrole-3-carboxamide moiety. These newly synthesized derivatives were evaluated for in vitro activity against selected cancer cell lines by MTT assay. Results revealed that some compounds exhibit broad-spectrum antitumor potency, and the most active compound 23p (IC50: 2.357–3.012 μM) was found more potent than Sunitinib (IC50: 31.594–49.036 μM) against HepG2, A549 and Skov-3, respectively. View Full-Text
Keywords: 5-bromo-7-azaindolin-2-ones; synthesis; antitumor activity 5-bromo-7-azaindolin-2-ones; synthesis; antitumor activity
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MDPI and ACS Style

Zhang, J.; Shen, W.; Li, X.; Chai, Y.; Li, S.; Lv, K.; Guo, H.; Liu, M. Synthesis and Antitumor Activity of 5-Bromo-7-azaindolin-2-one Derivatives Containing a 2,4-Dimethyl-1H-pyrrole-3-carboxamide Moiety. Molecules 2016, 21, 1674.

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