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Molecules 2016, 21(11), 1596;

4-Hydroxyisoleucine from Fenugreek (Trigonella foenum-graecum): Effects on Insulin Resistance Associated with Obesity

Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Juriquilla, Querétaro, Qro. 76230, Mexico
Nucitec S.A. de C.V. Querétaro, Qro. 76215, Mexico
Author to whom correspondence should be addressed.
Academic Editor: Min-Hsiung Pan
Received: 5 September 2016 / Revised: 31 October 2016 / Accepted: 10 November 2016 / Published: 22 November 2016
(This article belongs to the Special Issue Natural Products in Anti-Obesity Therapy)
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Obesity and insulin resistance (IR) are interdependent multifactorial processes that cannot be understood separately. Obesity leads to systemic inflammation and increased levels of free fatty acids that provoke IR and lipotoxicity. At the same time, IR exacerbates adipose cell dysfunction, resulting in chronic inflammation and major lipotoxic effects on nonadipose tissues. 4-Hydroxyisoleucine (4-OHIle), a peculiar nonprotein amino acid isolated from fenugreek (Trigonella foenum-graecum) seeds, exhibits interesting effects on IR related to obesity. 4-OHIle increases glucose-induced insulin release, and the insulin response mediated by 4-OHIle depends on glucose concentration. The beneficial effects observed are related to the regulation of blood glucose, plasma triglycerides, total cholesterol, free fatty acid levels, and the improvement of liver function. The mechanism of action is related to increased Akt phosphorylation and reduced activation of Jun N-terminal kinase (JNK)1/2, extracellular signal-regulated kinase (ERK)1/2, p38 mitogen-activated protein kinase (MAPK), and nuclear factor (NF)-κB. Here, we present a review of the research regarding the insulinotropic and insulin-sensitising activity of 4-OHIle in in vitro and in vivo models. View Full-Text
Keywords: 4-hydroxyisoleucine; Trigonella foenum-graecum; insulinotropic; fenugreek 4-hydroxyisoleucine; Trigonella foenum-graecum; insulinotropic; fenugreek

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Avalos-Soriano, A.; De la Cruz-Cordero, R.; Rosado, J.L.; Garcia-Gasca, T. 4-Hydroxyisoleucine from Fenugreek (Trigonella foenum-graecum): Effects on Insulin Resistance Associated with Obesity. Molecules 2016, 21, 1596.

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