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Article

Effect of the Aged Garlic Extract on Cardiovascular Function in Metabolic Syndrome Rats

1
Department of Pathology, Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico
2
Department of Pharmacology, Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico
3
Facultad de Química, Department of Biology, Edificio B, Segundo Piso, Laboratorio 209, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Mexico City 04510, Mexico
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Department of Physiology, Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico
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Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Vasco de Quiroga 15, Sección XVI, Tlalpan, Mexico City 14000, Mexico
6
Electromechanical Instrumentation, Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico
*
Author to whom correspondence should be addressed.
Israel Pérez-Torres and Juan Carlos Torres-Narváez, share the first authorship of this paper.
Academic Editor: Alan J. Slusarenko
Molecules 2016, 21(11), 1425; https://doi.org/10.3390/molecules21111425
Received: 29 September 2016 / Revised: 16 October 2016 / Accepted: 21 October 2016 / Published: 26 October 2016
(This article belongs to the Special Issue The Chemistry of Alliums)
The antioxidant properties of aged garlic extract (AGE) on cardiovascular functioning (CF) in metabolic syndrome (MS) remains poorly studied. Here we study the AGE effects on CF in a rat model of MS. Control rats plus saline solution (C + SS), MS rats (30% sucrose in drinking water from weaning) plus saline solution (MS + SS), control rats receiving AGE (C + AGE 125 mg/Kg/12 h) and MS rats with AGE (MS + AGE) were studied. MS + SS had increased triglycerides, systolic blood pressure, insulin, leptin, HOMA index, and advanced glycation end products. AGE returned their levels to control values (p < 0.01). Cholesterol was decreased by AGE (p = 0.05). Glutathion and GPx activity were reduced in MS + SS rats and increased with AGE (p = 0.05). Lipid peroxidation was increased in MS + SS and AGE reduced it (p = 0.001). Vascular functioning was deteriorated by MS (increased vasocontraction and reduced vasodilation) and AGE improved it (p = 0.001). Coronary vascular resistance was increased in MS rats and AGE decreased it (p = 0.001). Cardiac performance was not modified by MS but AGE increased it. NO measured in the perfusate liquid from the heart and serum citrulline, nitrites/nitrates were decreased in MS and AGE increased them (p < 0.01). In conclusion, AGE reduces MS-induced cardiovascular risk, through its anti-oxidant properties. View Full-Text
Keywords: aged garlic extract; metabolic syndrome; cardiovascular functioning; oxidative stress aged garlic extract; metabolic syndrome; cardiovascular functioning; oxidative stress
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MDPI and ACS Style

Pérez-Torres, I.; Torres-Narváez, J.C.; Pedraza-Chaverri, J.; Rubio-Ruiz, M.E.; Díaz-Díaz, E.; Del Valle-Mondragón, L.; Martínez-Memije, R.; Varela López, E.; Guarner-Lans, V. Effect of the Aged Garlic Extract on Cardiovascular Function in Metabolic Syndrome Rats. Molecules 2016, 21, 1425. https://doi.org/10.3390/molecules21111425

AMA Style

Pérez-Torres I, Torres-Narváez JC, Pedraza-Chaverri J, Rubio-Ruiz ME, Díaz-Díaz E, Del Valle-Mondragón L, Martínez-Memije R, Varela López E, Guarner-Lans V. Effect of the Aged Garlic Extract on Cardiovascular Function in Metabolic Syndrome Rats. Molecules. 2016; 21(11):1425. https://doi.org/10.3390/molecules21111425

Chicago/Turabian Style

Pérez-Torres, Israel, Juan C. Torres-Narváez, José Pedraza-Chaverri, María E. Rubio-Ruiz, Eulises Díaz-Díaz, Leonardo Del Valle-Mondragón, Raúl Martínez-Memije, Elvira Varela López, and Verónica Guarner-Lans. 2016. "Effect of the Aged Garlic Extract on Cardiovascular Function in Metabolic Syndrome Rats" Molecules 21, no. 11: 1425. https://doi.org/10.3390/molecules21111425

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