Next Article in Journal
Solasonine, A Natural Glycoalkaloid Compound, Inhibits Gli-Mediated Transcriptional Activity
Next Article in Special Issue
Expedient Organocatalytic Syntheses of 4-Substituted Pyrazolidines and Isoxazolidines
Previous Article in Journal
Thymol Mitigates Cadmium Stress by Regulating Glutathione Levels and Reactive Oxygen Species Homeostasis in Tobacco Seedlings
Previous Article in Special Issue
TBD- or PS-TBD-Catalyzed One-Pot Synthesis of Cyanohydrin Carbonates and Cyanohydrin Acetates from Carbonyl Compounds
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessReview
Molecules 2016, 21(10), 1327;

Recent Advances in Dynamic Kinetic Resolution by Chiral Bifunctional (Thio)urea- and Squaramide-Based Organocatalysts

2,* and 2,3,*
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei, China
Department of Chemistry, South University of Science and Technology of China, Shenzhen 518000, Guangdong, China
Authors to whom correspondence should be addressed.
Academic Editor: Raquel P. Herrera
Received: 29 August 2016 / Revised: 27 September 2016 / Accepted: 30 September 2016 / Published: 14 October 2016
(This article belongs to the Collection Recent Advances in Organocatalysis)
Full-Text   |   PDF [3133 KB, uploaded 18 October 2016]   |  


The organocatalysis-based dynamic kinetic resolution (DKR) process has proved to be a powerful strategy for the construction of chiral compounds. In this feature review, we summarized recent progress on the DKR process, which was promoted by chiral bifunctional (thio)urea and squaramide catalysis via hydrogen-bonding interactions between substrates and catalysts. A wide range of asymmetric reactions involving DKR, such as asymmetric alcoholysis of azlactones, asymmetric Michael–Michael cascade reaction, and enantioselective selenocyclization, are reviewed and demonstrate the efficiency of this strategy. The (thio)urea and squaramide catalysts with dual activation would be efficient for more unmet challenges in dynamic kinetic resolution. View Full-Text
Keywords: dynamic kinetic resolution; (thio)urea; squaramide dynamic kinetic resolution; (thio)urea; squaramide

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Li, P.; Hu, X.; Dong, X.-Q.; Zhang, X. Recent Advances in Dynamic Kinetic Resolution by Chiral Bifunctional (Thio)urea- and Squaramide-Based Organocatalysts. Molecules 2016, 21, 1327.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top