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Open AccessReview

Recent Advances in Dynamic Kinetic Resolution by Chiral Bifunctional (Thio)urea- and Squaramide-Based Organocatalysts

by Pan Li 1,2, Xinquan Hu 1, Xiu-Qin Dong 2,* and Xumu Zhang 2,3,*
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei, China
Department of Chemistry, South University of Science and Technology of China, Shenzhen 518000, Guangdong, China
Authors to whom correspondence should be addressed.
Academic Editor: Raquel P. Herrera
Molecules 2016, 21(10), 1327;
Received: 29 August 2016 / Revised: 27 September 2016 / Accepted: 30 September 2016 / Published: 14 October 2016
(This article belongs to the Collection Recent Advances in Organocatalysis)
The organocatalysis-based dynamic kinetic resolution (DKR) process has proved to be a powerful strategy for the construction of chiral compounds. In this feature review, we summarized recent progress on the DKR process, which was promoted by chiral bifunctional (thio)urea and squaramide catalysis via hydrogen-bonding interactions between substrates and catalysts. A wide range of asymmetric reactions involving DKR, such as asymmetric alcoholysis of azlactones, asymmetric Michael–Michael cascade reaction, and enantioselective selenocyclization, are reviewed and demonstrate the efficiency of this strategy. The (thio)urea and squaramide catalysts with dual activation would be efficient for more unmet challenges in dynamic kinetic resolution. View Full-Text
Keywords: dynamic kinetic resolution; (thio)urea; squaramide dynamic kinetic resolution; (thio)urea; squaramide
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MDPI and ACS Style

Li, P.; Hu, X.; Dong, X.-Q.; Zhang, X. Recent Advances in Dynamic Kinetic Resolution by Chiral Bifunctional (Thio)urea- and Squaramide-Based Organocatalysts. Molecules 2016, 21, 1327.

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