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Open AccessArticle

Effects of Sanguis Draconis on Perforator Flap Survival in Rats

Department of Medicine, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou 310007, Zhejiang, China
Department of Orthopedic Surgery, Lishui Central Hospital, Lishui 323000, Zhejiang, China
Department of Orthopedic Surgery, Zhejiang Provincial Tongde Hospital, Hangzhou 310012, Zhejiang, China
Author to whom correspondence should be addressed.
Academic Editor: Christopher W.K. Lam
Molecules 2016, 21(10), 1262;
Received: 20 July 2016 / Revised: 14 September 2016 / Accepted: 19 September 2016 / Published: 26 September 2016
(This article belongs to the Collection Herbal Medicine Research)
PDF [10511 KB, uploaded 26 September 2016]


Sanguis draconis, a resin known to improve blood circulation, relieve pain, stimulate tissue regeneration, and heal wounds, is widely used in clinical practice. In this study, we prepared an ethanol extract of sanguis draconis (EESD) containing 75.08 mg/g of dracorhodin. The experiment was carried out on 20 rats that were divided into two groups, a control group (n = 10) and an EESD group (n = 10). All the rats underwent a perforator flap surgery, after which post-operative abdominal compressions of EESD were given to the EESD group for seven days, while the control group received saline. Flap survival percentages were determined after seven days, and were found to be significantly higher in the EESD group than in the control group. Results of laser Doppler flowmetry (LDF) showed that perforator flaps in the EESD group had higher perfusion values than those of the control group. The flap tissues were stained with hematoxylin and eosin, followed by immunohistochemical evaluation. Superoxide dismutase (SOD) expression and micro-vessel development markedly increased in the EESD group, while malondialdehyde (MDA) levels decreased. This is the first study to investigate the effect of sanguis draconis on perforator flap survival. Our results demonstrate that sanguis draconis can improve perforator flap survival in rats by promoting microvessel regeneration and blood perfusion. View Full-Text
Keywords: sanguis draconis; dracorhodin; perforator flaps; flap survival; perfusion; microvessels sanguis draconis; dracorhodin; perforator flaps; flap survival; perfusion; microvessels

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Zhang, Y.; Cai, X.; Shen, L.; Huang, X.; Wang, X.; Lan, Y.; Shou, D. Effects of Sanguis Draconis on Perforator Flap Survival in Rats. Molecules 2016, 21, 1262.

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