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Molecules
Volume 20
Issue 9
10.3390/molecules200916388
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Article

Gallic Acid Is the Major Active Component of Cortex Moutan in Inhibiting Immune Maturation of Human Monocyte-Derived Dendritic Cells

by
Ben Chung Lap Chan
1,
Long Fei Li
1,
Shui Qing Hu
1,
Elaine Wat
1,
Eric Chun Wai Wong
1,
Vanilla Xin Zhang
1,
Clara Bik San Lau
1,
Chun Kwok Wong
1,2,
Kam Lun Ellis Hon
3,
Patrick Chi Leung Hui
4 and
Ping Chung Leung
1,*
1
State Key Laboratory of Phytochemistry and Plant Resources in West China, Institute of Chinese Medicine, the Chinese University of Hong Kong, Hong Kong, China
2
Department of Chemical Pathology, Prince of Wales Hospital, the Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
3
Department of Paediatrics, Prince of Wales Hospital, the Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
4
Institute of Textiles and Clothing, the Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2015, 20(9), 16388-16403; https://doi.org/10.3390/molecules200916388
Received: 5 August 2015 / Revised: 1 September 2015 / Accepted: 1 September 2015 / Published: 10 September 2015
(This article belongs to the Collection Herbal Medicine Research)
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Abstract

Atopic dermatitis (AD) is a widely prevalent and chronically relapsing inflammatory skin disease. Penta Herbs Formula (PHF) is efficacious in improving the quality of life and reducing topical corticosteroid used in children with AD and one of the active herbs it contains is Cortex Moutan. Recent studies showed that altered functions of dendritic cells (DC) were observed in atopic individuals, suggesting that DC might play a major role in the generation and maintenance of inflammation by their production of pro-inflammatory cytokines. Hence, the aims of the present study were to identify the major active component(s) of Cortex Moutan, which might inhibit DC functions and to investigate their possible interactions with conventional corticosteroid on inhibiting the development of DC from monocytes. Monocyte-derived dendritic cells (moDC) culture model coupled with the high-speed counter-current chromatography (HSCCC), high pressure liquid chromatography (HPLC) and Liquid Chromatography-Mass Spectrometry (LCMS) analyses were used. Gallic acid was the major active component from Cortex Moutan which could dose dependently inhibit interleukin (IL)-12 p40 and the functional cluster of differentiation (CD) surface markers CD40, CD80, CD83 and CD86 expression from cytokine cocktail-activated moDC. Gallic acid could also lower the concentration of hydrocortisone required to inhibit the activation of DC. View Full-Text
Keywords: atopic dermatitis; Cortex Moutan; dendritic cells; gallic acid; high-speed counter-current chromatography; Penta Herb Formula atopic dermatitis; Cortex Moutan; dendritic cells; gallic acid; high-speed counter-current chromatography; Penta Herb Formula
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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MDPI and ACS Style

Chan, B.C.L.; Li, L.F.; Hu, S.Q.; Wat, E.; Wong, E.C.W.; Zhang, V.X.; Lau, C.B.S.; Wong, C.K.; Hon, K.L.E.; Hui, P.C.L.; Leung, P.C. Gallic Acid Is the Major Active Component of Cortex Moutan in Inhibiting Immune Maturation of Human Monocyte-Derived Dendritic Cells. Molecules 2015, 20, 16388-16403. https://doi.org/10.3390/molecules200916388

AMA Style

Chan BCL, Li LF, Hu SQ, Wat E, Wong ECW, Zhang VX, Lau CBS, Wong CK, Hon KLE, Hui PCL, Leung PC. Gallic Acid Is the Major Active Component of Cortex Moutan in Inhibiting Immune Maturation of Human Monocyte-Derived Dendritic Cells. Molecules. 2015; 20(9):16388-16403. https://doi.org/10.3390/molecules200916388

Chicago/Turabian Style

Chan, Ben Chung Lap, Long Fei Li, Shui Qing Hu, Elaine Wat, Eric Chun Wai Wong, Vanilla Xin Zhang, Clara Bik San Lau, Chun Kwok Wong, Kam Lun Ellis Hon, Patrick Chi Leung Hui, and Ping Chung Leung. 2015. "Gallic Acid Is the Major Active Component of Cortex Moutan in Inhibiting Immune Maturation of Human Monocyte-Derived Dendritic Cells" Molecules 20, no. 9: 16388-16403. https://doi.org/10.3390/molecules200916388

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