Next Article in Journal
Antioxidant and Anti-Inflammatory Activities of a Natural Compound, Shizukahenriol, through Nrf2 Activation
Previous Article in Journal
Concise Synthesis of Broussonone A
Open AccessArticle

Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors

1
Department of Chemistry, Faculty of Science, Alexandria University, P. O. Box 426, Ibrahimia, Alexandria 21321, Egypt
2
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt
3
Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia
4
Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa
5
School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4001, South Africa
6
Institute for Research in Biomedicine and CIBER-BBN, Barcelona 08028, Spain
7
Department of Organic Chemistry, University of Barcelona, Barcelona 08028, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Molecules 2015, 20(9), 15976-15988; https://doi.org/10.3390/molecules200915976
Received: 22 May 2015 / Revised: 14 August 2015 / Accepted: 24 August 2015 / Published: 2 September 2015
(This article belongs to the Section Medicinal Chemistry)
Three series of 4,6-dimethoxy-, 4,6-dipiperidino- and 4,6-dimorpholino-1,3,5-triazin-2-yl) amino acid derivatives were synthesized and characterized. A preliminary study for their monoamine oxidase inhibitory activity showed that compounds 7, 18, and 25 had MAO-A inhibition activity comparable to that of the standard clorgyline, with apparently more selective inhibitory activity toward MAO-A than MAO-B and no significant acute toxicity. View Full-Text
Keywords: 1,3,5-triazine derivatives; amino acids; morpholine; piperidine; monoamine oxidase 1,3,5-triazine derivatives; amino acids; morpholine; piperidine; monoamine oxidase
Show Figures

Figure 1

MDPI and ACS Style

Khattab, S.N.; Khalil, H.H.; Bekhit, A.A.; El-Rahman, M.M.A.; El-Faham, A.; Albericio, F. Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors. Molecules 2015, 20, 15976-15988.

Show more citation formats Show less citations formats

Article Access Map

1
Only visits after 24 November 2015 are recorded.
Back to TopTop