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Article

Steroidal Saponins from the Roots and Rhizomes of Tupistra chinensis

1
Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China
2
The First Hospital of Xi'an, Xi'an 710002, China
3
School of Pharmaceutical Sciences, Xi'an Medical University, Xi'an 710021, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Derek J. McPhee
Molecules 2015, 20(8), 13659-13669; https://doi.org/10.3390/molecules200813659
Received: 25 June 2015 / Revised: 22 July 2015 / Accepted: 23 July 2015 / Published: 28 July 2015
(This article belongs to the Section Natural Products Chemistry)
Two new furostanol saponins 12 and a new spirostanol saponin 3 were isolated together with two known furostanol saponins 45 from the roots and rhizomes of Tupistra chinensis. Their structures were characterized as 1β,2β,3β,4β,5β,26-hexahydroxyfurost-20(22), 25(27)-dien-5,26-O-β-d-glucopyranoside (1), 1β,2β,3β,4β,5β,6β,7α,23ξ,26-nona-hydroxyfurost- 20(22),25(27)-dien-26-O-β-d-glucopyranoside (2), (20S,22R)-spirost-25 (27)-en-1β,3β,5β- trihydroxy-1-O-β-d-xyloside (3), tupisteroide B (4) and 5β-furost-Δ25(27)-en-1β,2β,3β,4β,5β,7α, 22ξ,26-octahydroxy-6-one-26-O-β-d-glucopyranoside (5), respectively, by extensive use of spectroscopic techniques and chemical evidence. Additionally, the in vitro cytotoxic activity of 14 was evaluated on human A549 and H1299 tumor cell lines, and compound 3 exhibited cytotoxicity against A549 cells (IC50 86.63 ± 2.33 μmol·L−1) and H1299 cells (IC50 88.21 ± 1.34 μmol·L−1). View Full-Text
Keywords: Tupistra chinensis; steroidal saponins; structure identification; cytotoxic activity Tupistra chinensis; steroidal saponins; structure identification; cytotoxic activity
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MDPI and ACS Style

Li, Y.; Wang, X.; He, H.; Zhang, D.; Jiang, Y.; Yang, X.; Wang, F.; Tang, Z.; Song, X.; Yue, Z. Steroidal Saponins from the Roots and Rhizomes of Tupistra chinensis. Molecules 2015, 20, 13659-13669. https://doi.org/10.3390/molecules200813659

AMA Style

Li Y, Wang X, He H, Zhang D, Jiang Y, Yang X, Wang F, Tang Z, Song X, Yue Z. Steroidal Saponins from the Roots and Rhizomes of Tupistra chinensis. Molecules. 2015; 20(8):13659-13669. https://doi.org/10.3390/molecules200813659

Chicago/Turabian Style

Li, Yuze; Wang, Xin; He, Hao; Zhang, Dongdong; Jiang, Yi; Yang, Xinjie; Wang, Fei; Tang, Zhishu; Song, Xiaomei; Yue, Zhenggang. 2015. "Steroidal Saponins from the Roots and Rhizomes of Tupistra chinensis" Molecules 20, no. 8: 13659-13669. https://doi.org/10.3390/molecules200813659

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