Next Article in Journal
Calophyllolide Content in Calophyllum inophyllum at Different Stages of Maturity and Its Osteogenic Activity
Next Article in Special Issue
Recent Developments and Biological Activities of N-Substituted Carbazole Derivatives: A Review
Previous Article in Journal
Quantification of Polyfunctional Thiols in Wine by HS-SPME-GC-MS Following Extractive Alkylation
Previous Article in Special Issue
Uses of 3-(2-Bromoacetyl)-2H-chromen-2-one in the Synthesis of Heterocyclic Compounds Incorporating Coumarin: Synthesis, Characterization and Cytotoxicity
Article Menu

Export Article

Open AccessArticle
Molecules 2015, 20(7), 12300-12313;

Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives

Department of Organic Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 41 Victor Babeş street, RO-400012 Cluj-Napoca, Romania
Department of Biochemistry and Biochemical Engineering, Babeş-Bolyai University of Cluj-Napoca, 11 Arany János street, RO-400028 Cluj-Napoca, Romania
Author to whom correspondence should be addressed.
Academic Editor: Wim Dehaen
Received: 2 June 2015 / Revised: 1 July 2015 / Accepted: 2 July 2015 / Published: 6 July 2015
(This article belongs to the Collection Heterocyclic Compounds)
Full-Text   |   PDF [842 KB, uploaded 6 July 2015]   |  


This paper describes the biocatalytic synthesis of new Mannich bases containing various heterocyclic rings (thiazole, furane, thiophene, pyridine) by applying the lipase catalyzed trimolecular condensation of the corresponding heterocyclic aldehydes with acetone and primary aromatic amines, in mild and eco-friendly reaction conditions. The obtained Mannich bases were acylated to their corresponding N-acetyl derivatives. All compounds were characterized by 1H-NMR, 13C-NMR and MS spectrometry. View Full-Text
Keywords: Mannich reaction; heterocyclic compounds; lipase; biocatalytic promiscuity Mannich reaction; heterocyclic compounds; lipase; biocatalytic promiscuity

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Leonte, D.; Bencze, L.C.; Paizs, C.; Irimie, F.D.; Zaharia, V. Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives. Molecules 2015, 20, 12300-12313.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top