In Vivo Nanodetoxication for Acute Uranium Exposure
by
Luis Guzmán 1,2,3, Esteban F. Durán-Lara 1,2, Wendy Donoso 1, Fabiane M. Nachtigall 2 and Leonardo S. Santos 1,2,*
Luis Guzmán 1,2,3, Esteban F. Durán-Lara 1,2, Wendy Donoso 1, Fabiane M. Nachtigall 2 and Leonardo S. Santos 1,2,*
1
Laboratory of Asymmetric Synthesis, Institute of Chemistry and Natural Resources, University of Talca, P.O. Box 747, Talca 3460000, Maule, Chile
2
Nanobiotechnology Division at Talca University, Fraunhofer Chile Research Foundation-Center for Systems Biotechnology, FCR-CSB, P.O. Box 747, Talca 3460000, Maule, Chile
3
Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, University of Talca, P.O. Box 747, Talca 3460000, Maule, Chile
*
Author to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Molecules 2015, 20(6), 11017-11033; https://doi.org/10.3390/molecules200611017
Received: 24 March 2015 / Revised: 28 May 2015 / Accepted: 1 June 2015 / Published: 15 June 2015
(This article belongs to the Section Medicinal Chemistry)
Accidental exposure to uranium is a matter of concern, as U(VI) is nephrotoxic in both human and animal models, and its toxicity is associated to chemical toxicity instead of radioactivity. We synthesized different PAMAM G4 and G5 derivatives in order to prove their interaction with uranium and their effect on the viability of red blood cells in vitro. Furthermore, we prove the effectiveness of the selected dendrimers in an animal model of acute uranium intoxication. The dendrimer PAMAM G4-Lys-Fmoc-Cbz demonstrated the ability to chelate the uranyl ion in vivo, improving the biochemical and histopathologic features caused by acute intoxication with uranium.
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Guzmán, L.; Durán-Lara, E.F.; Donoso, W.; Nachtigall, F.M.; Santos, L.S. In Vivo Nanodetoxication for Acute Uranium Exposure. Molecules 2015, 20, 11017-11033.
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