Molecules 2015, 20(4), 7097-7142; https://doi.org/10.3390/molecules20047097
A Survey of Marine Natural Compounds and Their Derivatives with Anti-Cancer Activity Reported in 2012
Wamtinga Richard Sawadogo 1,2, Rainatou Boly 2, Claudia Cerella 1, Marie Hélène Teiten 1, Mario Dicato 1 and Marc Diederich 1,2,3,*
1
Laboratoire de Biologie Moléculaire et Cellulaire de Cancer, Hôpital Kirchberg, 9, rue Edward Steichen, L-2540 Luxembourg, Luxembourg
2
Institut de Recherche en Sciences de la Santé (IRSS), 03 BP 7192 Ouagadougou 03, Burkina Faso
3
College of Pharmacy, Seoul National University, Seoul 151-742, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 21 January 2015 / Revised: 1 April 2015 / Accepted: 3 April 2015 / Published: 20 April 2015
(This article belongs to the Collection Novel Drug Candidates for Anticancer Therapy: Design, Preliminary Evaluations, and Further Developments)
Abstract
Although considerable effort and progress has been made in the search for new anticancer drugs and treatments in the last several decades, cancer remains a major public health problem and one of the major causes of death worldwide. Many sources, including plants, animals, and minerals, are of interest in cancer research because of the possibility of identifying novel molecular therapeutics. Moreover, structure-activity-relationship (SAR) investigations have become a common way to develop naturally derived or semi-synthetic molecular analogues with improved efficacy and decreased toxicity. In 2012, approximately 138 molecules from marine sources, including isolated compounds and their associated analogues, were shown to be promising anticancer drugs. Among these, 62% are novel compounds. In this report, we review the marine compounds identified in 2012 that may serve as novel anticancer drugs. View Full-TextKeywords:
anticancer molecules; marine origin; synthetic derivatives; cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Sawadogo, W.R.; Boly, R.; Cerella, C.; Teiten, M.H.; Dicato, M.; Diederich, M. A Survey of Marine Natural Compounds and Their Derivatives with Anti-Cancer Activity Reported in 2012. Molecules 2015, 20, 7097-7142.
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