Next Article in Journal
Inhibition of Oxidative Stress and Skin Aging-Related Enzymes by Prenylated Chalcones and Other Flavonoids from Helichrysum teretifolium
Next Article in Special Issue
5-Methoxyquinoline Derivatives as a New Class of EZH2 Inhibitors
Previous Article in Journal
Glycodendrimers and Modified ELISAs: Tools to Elucidate Multivalent Interactions of Galectins 1 and 3
Previous Article in Special Issue
Synthesis and Pharmacophore Modelling of 2,6,9-Trisubstituted Purine Derivatives and Their Potential Role as Apoptosis-Inducing Agents in Cancer Cell Lines
Article Menu

Export Article

Open AccessReview
Molecules 2015, 20(4), 7097-7142;

A Survey of Marine Natural Compounds and Their Derivatives with Anti-Cancer Activity Reported in 2012

Laboratoire de Biologie Moléculaire et Cellulaire de Cancer, Hôpital Kirchberg, 9, rue Edward Steichen, L-2540 Luxembourg, Luxembourg
Institut de Recherche en Sciences de la Santé (IRSS), 03 BP 7192 Ouagadougou 03, Burkina Faso
College of Pharmacy, Seoul National University, Seoul 151-742, Korea
Author to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 21 January 2015 / Revised: 1 April 2015 / Accepted: 3 April 2015 / Published: 20 April 2015


Although considerable effort and progress has been made in the search for new anticancer drugs and treatments in the last several decades, cancer remains a major public health problem and one of the major causes of death worldwide. Many sources, including plants, animals, and minerals, are of interest in cancer research because of the possibility of identifying novel molecular therapeutics. Moreover, structure-activity-relationship (SAR) investigations have become a common way to develop naturally derived or semi-synthetic molecular analogues with improved efficacy and decreased toxicity. In 2012, approximately 138 molecules from marine sources, including isolated compounds and their associated analogues, were shown to be promising anticancer drugs. Among these, 62% are novel compounds. In this report, we review the marine compounds identified in 2012 that may serve as novel anticancer drugs. View Full-Text
Keywords: anticancer molecules; marine origin; synthetic derivatives; cancer anticancer molecules; marine origin; synthetic derivatives; cancer

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Sawadogo, W.R.; Boly, R.; Cerella, C.; Teiten, M.H.; Dicato, M.; Diederich, M. A Survey of Marine Natural Compounds and Their Derivatives with Anti-Cancer Activity Reported in 2012. Molecules 2015, 20, 7097-7142.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top