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Molecules 2015, 20(4), 6715-6738;

Studies on the Alkaloids of the Calycanthaceae and Their Syntheses

Chemical Biology Center, Lishui Institute of Agricultural Sciences, 827 Liyang Street, Lishui 323000, Zhejiang, China
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 14 February 2015 / Revised: 18 March 2015 / Accepted: 3 April 2015 / Published: 15 April 2015
(This article belongs to the Collection Bioactive Compounds)
Full-Text   |   PDF [1388 KB, uploaded 15 April 2015]   |  


Plants of the Calycanthaceae family, which possesses four genera and about 15 species, are mainly distributed in China, North America and Australia. Chemical studies on the Calycanthaceae have led to the discovery of about 14 alkaloids of different skeletons, including dimeric piperidinoquinoline, dimeric pyrrolidinoindoline and/or trimeric pyrrolidinoindolines, which exhibit significant anti-convulsant, anti-fungal, anti-viral analgesic, anti-tumor, and anti-melanogenesis activities. As some of complex tryptamine-derived alkaloids exhibit promising biological activities, the syntheses of these alkaloids have also been a topic of interest in synthetic chemistry during the last decades. This review will focus on the structures and total syntheses of these alkaloids. View Full-Text
Keywords: biological activity; biosynthesis; Calycanthaceae alkaloids; structure; synthesis biological activity; biosynthesis; Calycanthaceae alkaloids; structure; synthesis

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Xu, J.-B.; Cheng, K.-J. Studies on the Alkaloids of the Calycanthaceae and Their Syntheses. Molecules 2015, 20, 6715-6738.

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