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Keywords = Calycanthaceae alkaloids

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24 pages, 1388 KiB  
Review
Studies on the Alkaloids of the Calycanthaceae and Their Syntheses
by Jin-Biao Xu and Ke-Jun Cheng
Molecules 2015, 20(4), 6715-6738; https://doi.org/10.3390/molecules20046715 - 15 Apr 2015
Cited by 28 | Viewed by 10197
Abstract
Plants of the Calycanthaceae family, which possesses four genera and about 15 species, are mainly distributed in China, North America and Australia. Chemical studies on the Calycanthaceae have led to the discovery of about 14 alkaloids of different skeletons, including dimeric piperidinoquinoline, dimeric [...] Read more.
Plants of the Calycanthaceae family, which possesses four genera and about 15 species, are mainly distributed in China, North America and Australia. Chemical studies on the Calycanthaceae have led to the discovery of about 14 alkaloids of different skeletons, including dimeric piperidinoquinoline, dimeric pyrrolidinoindoline and/or trimeric pyrrolidinoindolines, which exhibit significant anti-convulsant, anti-fungal, anti-viral analgesic, anti-tumor, and anti-melanogenesis activities. As some of complex tryptamine-derived alkaloids exhibit promising biological activities, the syntheses of these alkaloids have also been a topic of interest in synthetic chemistry during the last decades. This review will focus on the structures and total syntheses of these alkaloids. Full article
(This article belongs to the Collection Bioactive Compounds)
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