Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives

Ledeţi, Ionuţ; Avram, Ştefana; Bercean, Vasile; Vlase, Gabriela; Vlase, Titus; Ledeţi, Adriana; Zupko, Istvan; Mioc, Marius; Şuta, Lenuţa-Maria; Şoica, Codruţa; Dehelean, Cristina

doi:10.3390/molecules201219876

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Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives

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Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania

Faculty of Industrial Chemistry and Environmental Engineering, Politehnica University Timişoara, 6 Carol Telbisz, 300001 Timisoara, Romania

Research Centre for Thermal Analysis in Environmental Problems, West University of Timişoara, 300115 Timisoara, Romania

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Department of Pharmacodynamics and Biopharmacy, University of Szeged, 6 Eotvos Str., H-6720 Szeged, Hungary

Authors to whom correspondence should be addressed.

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These authors contributed equally to this work.

Academic Editor: Derek J. McPhee

Molecules 2015, 20(12), 22691-22702; https://doi.org/10.3390/molecules201219876

Received: 1 November 2015 / Revised: 4 December 2015 / Accepted: 7 December 2015 / Published: 18 December 2015

(This article belongs to the Section Natural Products Chemistry)

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Abstract

Betulonic acid belongs to the pentacyclic triterpenic derivative class and can be obtained through the selective oxidation of betulin. In this study we set obtaining several functionalized derivatives of this compound by its condensation with several amino compounds such as aminoguanidine, hydroxylamine, n-butylamine and thiosemicarbazide as our goal. The functionalization of the parent compound led to several molecules with antiproliferative potential, the most promising being 3–2-carbamothioylhydrazonolup-20(29)-en-28-oic acid. View Full-Text

Keywords: betulonic acid derivatives; triterpene; thermal analysis; synthesis; biological activity; MTT assay

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Ledeţi, I.; Avram, Ş.; Bercean, V.; Vlase, G.; Vlase, T.; Ledeţi, A.; Zupko, I.; Mioc, M.; Şuta, L.-M.; Şoica, C.; Dehelean, C. Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives. Molecules 2015, 20, 22691-22702. https://doi.org/10.3390/molecules201219876

AMA Style

Ledeţi I, Avram Ş, Bercean V, Vlase G, Vlase T, Ledeţi A, Zupko I, Mioc M, Şuta L-M, Şoica C, Dehelean C. Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives. Molecules. 2015; 20(12):22691-22702. https://doi.org/10.3390/molecules201219876

Chicago/Turabian Style

Ledeţi, Ionuţ, Ştefana Avram, Vasile Bercean, Gabriela Vlase, Titus Vlase, Adriana Ledeţi, Istvan Zupko, Marius Mioc, Lenuţa-Maria Şuta, Codruţa Şoica, and Cristina Dehelean. 2015. "Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives" Molecules 20, no. 12: 22691-22702. https://doi.org/10.3390/molecules201219876

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