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Open AccessArticle

Protective Effects of Red Guava on Inflammation and Oxidative Stress in Streptozotocin-Induced Diabetic Mice

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Department of Health and Nutrition Biotechnology, Asia University, Taichung 41354, Taiwan
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School of Pharmacy, College of Pharmacy, China Medical University, Taichung 40402, Taiwan
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Department of Nutrition, Chung Shan Medical University, Taichung, 40201, Taiwan
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Department of Nutrition, China Medical University, Taichung 40402, Taiwan
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Department of Biotechnology, Asia University, Taichung 41354, Taiwan
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Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40402, Taiwan
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Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40447, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2015, 20(12), 22341-22350; https://doi.org/10.3390/molecules201219831
Received: 13 November 2015 / Revised: 2 December 2015 / Accepted: 3 December 2015 / Published: 12 December 2015
(This article belongs to the Section Natural Products Chemistry)
Diabetes is an important chronic disease and the 4th leading cause of death in Taiwan. Hyperglycemia-induced oxidative and inflammatory damage are the main causes of chronic complications in diabetic patients. The red guava (red-fleshed guava cultivar of Psidium guajava L.) is a tropical fruit belonging to the Myrtaceae family and an important commercial crop in Taiwan. In this study, the protective effects of a diet containing red guava on inflammation and oxidative stress in streptozotocin (STZ)-induced diabetic mice were examined. The experimental group was divided into seven subgroups: normal (N), diabetes mellitus (DM), diabetes + red guava 1% (L), 2% (M), and 5% (H), diabetes + 5% red guava + anti-diabetic rosiglitazone (HR), and diabetes + anti-diabetic rosiglitazone (R). The mice were fed for 8 weeks and sacrificed by decapitation. Compared with the DM group, the experimental groups with diets containing red guava as well as rosiglitazone all showed significant improvements in blood glucose control, insulin resistance, creatinine, blood urea nitrogen, triglycerides, non-esterified fatty acids, cholesterol, c-reactive protein, TNF-α, and IL-10. Furthermore, the expression of inflammatory proteins, such as iNOS and NF-κB, was suppressed via activated PPARγ, and the expression levels of GPx3 and ACO increased. In summary, red guava can significantly suppress inflammatory and oxidative damage caused by diabetes and alleviate diabetic symptoms; thus, it exerts protective effects and has potential applications for the development of a dietary supplement. View Full-Text
Keywords: red guava; diabetes; anti-inflammation; oxidative stress red guava; diabetes; anti-inflammation; oxidative stress
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MDPI and ACS Style

Li, P.-Y.; Hsu, C.-C.; Yin, M.-C.; Kuo, Y.-H.; Tang, F.-Y.; Chao, C.-Y. Protective Effects of Red Guava on Inflammation and Oxidative Stress in Streptozotocin-Induced Diabetic Mice. Molecules 2015, 20, 22341-22350.

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