Next Article in Journal
A Copper-Based Metal-Organic Framework as an Efficient and Reusable Heterogeneous Catalyst for Ullmann and Goldberg Type C–N Coupling Reactions
Next Article in Special Issue
Characterization of Amorphous and Co-Amorphous Simvastatin Formulations Prepared by Spray Drying
Previous Article in Journal
Apigenin Attenuates Melanoma Cell Migration by Inducing Anoikis through Integrin and Focal Adhesion Kinase Inhibition
Previous Article in Special Issue
Development and Evaluation of Liquid and Solid Self-Emulsifying Drug Delivery Systems for Atorvastatin
Open AccessArticle

Improved Antioxidant Capacity of Optimization of a Self-Microemulsifying Drug Delivery System for Resveratrol

College of Life Sciences, Henan Normal University, Xinxiang 453007, China
College of Life Science and Biotechnology, Xinxiang Medical University, Xinxiang 453003, China
School of Life Science and Technology, Henan Institute of Science and Technology, Xinxiang 453003, China
Author to whom correspondence should be addressed.
Academic Editors: Thomas Rades, Holger Grohganz and Korbinian Löbmann
Molecules 2015, 20(12), 21167-21177;
Received: 16 September 2015 / Revised: 13 November 2015 / Accepted: 17 November 2015 / Published: 27 November 2015
(This article belongs to the Collection Poorly Soluble Drugs)
The use of nano-encapsulated resveratrol (RSV) in self-micro-emulsified drug delivery systems (SMEDDS) formulations was investigated. Self-emulsifying grading tests were used to establish the optimal ratio of oil, surfactant, and co-surfactant. The optimized system was further investigated for the droplet size and zeta potential at the different medium pH values by a Malvern Zetasizer and transmission electron microscopy (TEM). The antioxidant capacity and cytotoxicity of the formulation were detected by DCFH-DA and a CCK-8 assays. The results showed that the nano-emulsion based on ethyl oleate, Tween-80, and PEG-400 (35:40:25, w/w/w) was the most stable formulation due to the small droplet size (approximately 50 nm) and high zeta potential in a neutral environment. Furthermore, this formulation also exhibited a greater antioxidant capacity with less toxicity than free RSV. Taken together, considering these results and the simple fabrication process, this formulation could be used to deliver nutritional food supplements in a stable, efficient, and safe manner. View Full-Text
Keywords: resveratrol; nano-encapsulation; self-emulsifying; oil-in-water; antioxidant; cytotoxicity resveratrol; nano-encapsulation; self-emulsifying; oil-in-water; antioxidant; cytotoxicity
Show Figures

Figure 1

MDPI and ACS Style

Chen, Y.; Zhang, H.; Yang, J.; Sun, H. Improved Antioxidant Capacity of Optimization of a Self-Microemulsifying Drug Delivery System for Resveratrol. Molecules 2015, 20, 21167-21177.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop