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Molecules 2015, 20(11), 20397-20408;

Hydrogel-Based Drug Delivery Systems for Poorly Water-Soluble Drugs

Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, 4588 Parkview Place, St. Louis, MO 63110, USA
Author to whom correspondence should be addressed.
Academic Editors: Thomas Rades, Holger Grohganz and Korbinian Löbmann
Received: 13 October 2015 / Revised: 2 November 2015 / Accepted: 6 November 2015 / Published: 13 November 2015
(This article belongs to the Collection Poorly Soluble Drugs)
Full-Text   |   PDF [771 KB, uploaded 13 November 2015]   |  


Hydrogels are three-dimensional materials that can withstand a great amount of water incorporation while maintaining integrity. This allows hydrogels to be very unique biomedical materials, especially for drug delivery. Much effort has been made to incorporate hydrophilic molecules in hydrogels in the field of drug delivery, while loading of hydrophobic drugs has not been vastly studied. However, in recent years, research has also been conducted on incorporating hydrophobic molecules within hydrogel matrices for achieving a steady release of drugs to treat various ailments. Here, we summarize the types of hydrogels used as drug delivery vehicles, various methods to incorporate hydrophobic molecules in hydrogel matrices, and the potential therapeutic applications of hydrogels in cancer. View Full-Text
Keywords: hydrogels; thermosensitive; block copolymers; hydrophobic drugs hydrogels; thermosensitive; block copolymers; hydrophobic drugs

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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McKenzie, M.; Betts, D.; Suh, A.; Bui, K.; Kim, L.D.; Cho, H. Hydrogel-Based Drug Delivery Systems for Poorly Water-Soluble Drugs. Molecules 2015, 20, 20397-20408.

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