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Open AccessArticle

Cytotoxic Activities, SAR and Anti-Invasion Effects of Butylphthalide Derivatives on Human Hepatocellular Carcinoma SMMC7721 Cells

1
Laboratory of Metabolic Disease Research and Drug Development, China Medical University, Shenyang 110001, China
2
Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang 110819, China
3
Cancer Research Center, Key Laboratory of Brain and Spinal Cord Injury of Liaoning Province, and Laboratory Animal Center, the First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, China
*
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Molecules 2015, 20(11), 20312-20319; https://doi.org/10.3390/molecules201119699
Received: 25 September 2015 / Revised: 28 October 2015 / Accepted: 6 November 2015 / Published: 12 November 2015
(This article belongs to the Collection Bioactive Compounds)
A series of butylphthalide derivatives (BPDs) 18 were isolated from the extract of the dried rhizome of Ligusticum chuanxiong Hort. (Umbelliferae). The cytotoxic activities of BPDs 18 were evaluated using a panel of human cancer cell lines. In addition, the SAR analysis and potential anti-invasion activities were investigated. The sp2 carbons at C-7 and C-7a appeared to be essential for the cytotoxic activities of BPDs. BPDs 5 and 6 remarkably inhibited the migration and invasion of cancer cells. The anti-invasion activity of dimer 6 was demonstrated to be significantly higher than monomer 5. View Full-Text
Keywords: Ligusticum chuanxiong; butylphthalides; cytotoxic activity; SAR; anti-invasion Ligusticum chuanxiong; butylphthalides; cytotoxic activity; SAR; anti-invasion
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MDPI and ACS Style

Hu, Y.; Bi, X.; Zhao, P.; Zheng, H.; Huang, X. Cytotoxic Activities, SAR and Anti-Invasion Effects of Butylphthalide Derivatives on Human Hepatocellular Carcinoma SMMC7721 Cells. Molecules 2015, 20, 20312-20319.

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