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Synthesis of Novel bis-1,5-Disubstituted-1H-Tetrazoles by an Efficient Catalyst-Free Ugi-Azide Repetitive Process

1
Departamento Química Área Ambiental, Universidad Tecnológica de Salamanca, Av. Universidad Tecnológica No. 200, Col. Ciudad Bajío, Salamanca C.P. 36750, Gto., Mexico
2
Departamento de Química, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, Guanajuato C.P. 36050, Gto., Mexico
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Derek J. McPhee
Molecules 2015, 20(1), 1519-1526; https://doi.org/10.3390/molecules20011519
Received: 26 November 2014 / Accepted: 25 December 2014 / Published: 16 January 2015
(This article belongs to the Section Organic Chemistry)
A series of five novel bis-1,5-disubstituted-1H-tetrazoles (bis-1,5-DS-1H-T) were quickly prepared by a catalyst-free Ugi-azide repetitive process from easily accessible starting materials in excellent yields, either at room temperature (88%–95%) or using mild MW-heating conditions (80%–91%). These molecules may have a wide range of applications, such as chelating agents, organocatalysts and luminescent materials, and mainly as bioactive compounds. View Full-Text
Keywords: bis-1,5-disubstituted-1H-tetrazoles; Ugi-azide repetitive reaction; MW-assisted synthesis; catalyst-free; chelating agents bis-1,5-disubstituted-1H-tetrazoles; Ugi-azide repetitive reaction; MW-assisted synthesis; catalyst-free; chelating agents
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MDPI and ACS Style

Cárdenas-Galindo, L.E.; Islas-Jácome, A.; Colmenero-Martínez, K.M.; Martínez-Richa, A.; Gámez-Montaño, R. Synthesis of Novel bis-1,5-Disubstituted-1H-Tetrazoles by an Efficient Catalyst-Free Ugi-Azide Repetitive Process. Molecules 2015, 20, 1519-1526. https://doi.org/10.3390/molecules20011519

AMA Style

Cárdenas-Galindo LE, Islas-Jácome A, Colmenero-Martínez KM, Martínez-Richa A, Gámez-Montaño R. Synthesis of Novel bis-1,5-Disubstituted-1H-Tetrazoles by an Efficient Catalyst-Free Ugi-Azide Repetitive Process. Molecules. 2015; 20(1):1519-1526. https://doi.org/10.3390/molecules20011519

Chicago/Turabian Style

Cárdenas-Galindo, Luís E.; Islas-Jácome, Alejandro; Colmenero-Martínez, Karla M.; Martínez-Richa, Antonio; Gámez-Montaño, Rocío. 2015. "Synthesis of Novel bis-1,5-Disubstituted-1H-Tetrazoles by an Efficient Catalyst-Free Ugi-Azide Repetitive Process" Molecules 20, no. 1: 1519-1526. https://doi.org/10.3390/molecules20011519

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