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An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus

Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Science, Beijing Normal University, Beijing 100875, China
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Academic Editor: John A. Beutler
Molecules 2015, 20(1), 1424-1433; https://doi.org/10.3390/molecules20011424
Received: 27 October 2014 / Accepted: 5 January 2015 / Published: 14 January 2015
(This article belongs to the Section Natural Products Chemistry)
Two new compounds, fumitremorgin 12-methoxy-13-[5'-hydroxy-2'-(1''-hydroxy-3''-methoxy-5''-methylbenzoyl)-3'-methoxy]benzoic acid methyl ester (fumitremorgin D, 1) and 4,8,10,14-tetramethyl-6-acetoxy-14-[16-acetoxy-19-(20,21-dimethyl)-18-ene]-phenanthrene-1-ene-3,7-dione (2) were isolated from the cultured endophytic isolated fungus Aspergillus fumigatus, together with fourteen known compounds. Their structures were elucidated by 1-D and 2-D NMR analyses. The cytotoxicity profile of the compound against the human hepatocellular carcinoma cell line HepG2 was evaluated by MTT antiproliferative assays. View Full-Text
Keywords: Diphylleia sinensis L; Aspergillus fumigates; indolediketopiperazine alkaloids; steroid; cytotoxicity Diphylleia sinensis L; Aspergillus fumigates; indolediketopiperazine alkaloids; steroid; cytotoxicity
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Liang, Z.; Zhang, T.; Zhang, X.; Zhang, J.; Zhao, C. An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus. Molecules 2015, 20, 1424-1433.

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