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Magnetite Nanostructures as Novel Strategies for Anti-Infectious Therapy

Nanophysics Department, Istituto Italiano di Tecnologia (IIT), via Morego 30, Genova 16163, Italy
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street No. 1-7, Bucharest 011061, Romania
Microbiology and Immunology Department, Faculty of Biology, University of Bucharest, Aleea Portocalelor, No. 1-3, Bucharest 060101, Romania
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2014, 19(8), 12710-12726;
Received: 5 June 2014 / Revised: 8 August 2014 / Accepted: 11 August 2014 / Published: 20 August 2014
(This article belongs to the Special Issue Bio and Nanomaterials Based on Fe3O4)
This review highlights the current situation of antimicrobial resistance and the use of magnetic nanoparticles (MNPs) in developing novel routes for fighting infectious diseases. The most important two directions developed recently are: (i) improved delivery of antimicrobial compounds based on a drastic decrease of the minimal inhibition concentration (MIC) of the drug used independently; and (ii) inhibition of microbial attachment and biofilm development on coated medical surfaces. These new directions represent promising alternatives in the development of new strategies to eradicate and prevent microbial infections that involve resistant and biofilm-embedded bacteria. Recent promising applications of MNPs, as the development of delivery nanocarriers and improved nanovehicles for the therapy of different diseases are discussed, together with the mechanisms of microbial inhibition. View Full-Text
Keywords: infectious diseases; antimicrobials; antibiotics; magnetic nanoparticles; drug delivery infectious diseases; antimicrobials; antibiotics; magnetic nanoparticles; drug delivery
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MDPI and ACS Style

Liakos, I.; Grumezescu, A.M.; Holban, A.M. Magnetite Nanostructures as Novel Strategies for Anti-Infectious Therapy. Molecules 2014, 19, 12710-12726.

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