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Molecules 2014, 19(8), 11883-11895;

Synephrine Inhibits Eotaxin-1 Expression via the STAT6 Signaling Pathway

Biospectrum Life Science Institute, Sangdaewon-Dong, Seongnam-City, Gyeonggi-Do 442-13, Korea
Authors to whom correspondence should be addressed.
Received: 25 June 2014 / Revised: 30 July 2014 / Accepted: 30 July 2014 / Published: 8 August 2014
(This article belongs to the Section Natural Products Chemistry)
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Citrus contain various flavonoids and alkaloids that have multiple biological activities. It is known that the immature Citrus contains larger amounts of bioactive components, than do the mature plants. Although Citrus flavonoids are well known for their biological activities, Citrus alkaloids have not previously been assessed. In this study, we identified synephrine alkaloids as an active compound from immature Citrus unshiu, and investigated the effect of synephrine on eotaxin-1 expression. Eotaxin-1 is a potent chemoattractant for eosinophils, and a critical mediator, during the development of eosinophilic inflammation. We found that synephrine significantly inhibited IL-4-induced eotaxin-1 expression. This synephrine effect was mediated through the inhibition of STAT6 phosphorylation in JAK/STAT signaling. We also found that eosinophil recruitment induced by eotaxin-1 overexpression was inhibited by synephrine. Taken together, these findings indicate that inhibiting IL-4-induced eotaxin-1 expression by synephrine occurs primarily through the suppression of eosinophil recruitment, which is mediated by inhibiting STAT6 phosphorylation. View Full-Text
Keywords: Citrus unshiu; synephrine; STAT6; eotaxin-1; eosinophils Citrus unshiu; synephrine; STAT6; eotaxin-1; eosinophils

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Roh, K.-B.; Kim, I.-H.; Kim, Y.-S.; Lee, M.; Lee, J.-A.; Jung, E.; Park, D. Synephrine Inhibits Eotaxin-1 Expression via the STAT6 Signaling Pathway. Molecules 2014, 19, 11883-11895.

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