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Molecules 2014, 19(6), 7757-7769;

Salidroside Protects Caenorhabditis elegans Neurons from Polyglutamine-Mediated Toxicity by Reducing Oxidative Stress

School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
Research & Development Centre, Infinitus (China) Company Ltd, Guangzhou 510665, China
Guangdong Province Key Laboratory for Biotechnology Drug Candidates, School of Biosciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 4 May 2014 / Revised: 30 May 2014 / Accepted: 5 June 2014 / Published: 10 June 2014
(This article belongs to the Special Issue Natural Antioxidants and Ageing)
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Polyglutamine (polyQ) aggregation plays a pivotal role in the pathological process of Huntington’s disease and other polyQ disorders. Therefore, strategies aiming at restoring dysfunction and reducing stresses mediated by polyQ toxicity are of therapeutic interest for proteotoxicity diseases. Salidroside, a glycoside from Rhodiola rosea, has been shown to have a variety of bioactivities, including antioxidant activity. Using transgenic Caenorhabditis elegans models, we show here that salidroside is able to reduce neuronal death and behavioral dysfunction mediated by polyQ expressed in ASH neurons, but the neuroprotective effect is not associated with prevention of polyQ aggregation per se. Further experiments reveal that the neuroprotective effect of salidroside in C. elegans models involves its antioxidant capabilities, including decrease of ROS levels and paraquat-induced mortality, increase of antioxidant enzyme activities and reduction of lipid peroxidation. These results demonstrate that salidroside exerts its neuroprotective function against polyQ toxicity via oxidative stress pathways. View Full-Text
Keywords: salidroside; polyglutamine; neurotoxicity; oxidative stress; C. elegans; chemoavoidance salidroside; polyglutamine; neurotoxicity; oxidative stress; C. elegans; chemoavoidance

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Xiao, L.; Li, H.; Zhang, J.; Yang, F.; Huang, A.; Deng, J.; Liang, M.; Ma, F.; Hu, M.; Huang, Z. Salidroside Protects Caenorhabditis elegans Neurons from Polyglutamine-Mediated Toxicity by Reducing Oxidative Stress. Molecules 2014, 19, 7757-7769.

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