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Molecules 2014, 19(5), 5611-5623;

miRNAs for the Detection of MultiDrug Resistance: Overview and Perspectives

Institute for Biomedical Technologies, CNR Bioinformatics and Genomics Research Group, Via Amendola 122/D, Bari 70126, Italy
Biofordrug srl, Università degli Studi di Bari, via Orabona 4, Bari 70125, Italy
Clinical and Preclinical Pharmacology Laboratory, National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, Viale O. Flacco, 65, Bari 70124, Italy
Università degli Studi di Bari "Aldo Moro", Via Orabona 4, Bari 70125, Italy
Author to whom correspondence should be addressed.
Received: 18 February 2014 / Revised: 23 April 2014 / Accepted: 25 April 2014 / Published: 30 April 2014
(This article belongs to the Special Issue miRNAs as Probes to Monitor Cancer and Neurodegenerative Disorders)
Full-Text   |   PDF [200 KB, uploaded 18 June 2014]


The goal of the present paper is to establish and validate the link between cancer diagnosis and therapy by microRNAs detection. The induction in vitro of some specific microRNAs after treatment with MDR ligands has been outlined. Starting from the results obtained by in vitro induction of MDCK and MDCK-MDR1 cells treated by a MDR1 ligand, a new scenario in the early diagnosis and chemotherapy could be disclosed. To corroborate this perspective a short overview on pancreatic cancer diagnosis and chemotherapeutic treatment has been reported. View Full-Text
Keywords: microRNAs; MDR; early diagnosis; MDCK-MDR1; P-glycoprotein microRNAs; MDR; early diagnosis; MDCK-MDR1; P-glycoprotein
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Gisel, A.; Valvano, M.; El Idrissi, I.G.; Nardulli, P.; Azzariti, A.; Carrieri, A.; Contino, M.; Colabufo, N.A. miRNAs for the Detection of MultiDrug Resistance: Overview and Perspectives. Molecules 2014, 19, 5611-5623.

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