Next Article in Journal
Three New Ring-A Modified Ursane Triterpenes from Davidia involucrata
Previous Article in Journal
Identification of Absorbed Constituents in the Rabbit Plasma and Cerebrospinal Fluid after Intranasal Administration of Asari Radix et Rhizoma by HS-SPME-GC-MS and HPLC-APCI-IT-TOF-MSn
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(4), 4880-4896;

Kinetics of Glycoxidation of Bovine Serum Albumin by Methylglyoxal and Glyoxal and its Prevention by Various Compounds

Department of Biochemistry and Cell Biology, University of Rzeszów, Zelwerowicza St. 4, PL 35-601 Rzeszów, Poland
Department of Molecular Biophysics, University of Łódź, Pomorska 141/143, 90-236 Łódź, Poland
Author to whom correspondence should be addressed.
Received: 19 February 2014 / Revised: 9 March 2014 / Accepted: 10 March 2014 / Published: 17 April 2014
(This article belongs to the Section Medicinal Chemistry)
Full-Text   |   PDF [686 KB, uploaded 18 June 2014]   |  


The aim of this study was to compare several methods for measurement of bovine serum albumin (BSA) modification by glycoxidation with reactive dicarbonyl compounds (methylglyoxal ‒ MGO and glyoxal ‒ GO), for studies of the kinetics of this process and to compare the effects of 19 selected compounds on BSA glycation by the aldehydes. The results confirm the higher reactivity of MGO with respect to GO and point to the usefulness of AGE, dityrosine and N′-formylkynurenine fluorescence for monitoring glycation and evaluation of protection against glycation. Different extent of protection against glycation induced by MGO and GO was found for many compounds, probably reflecting effects on various stages of the glycation process. Polyphenols (genistein, naringin and ellagic acid) were found to protect against aldehyde-induced glycation; 1-cyano-4-hydroxycinnamic acid was also an effective protector. View Full-Text
Keywords: glycation; kinetics; methylglyoxal; glyoxal; antioxidants glycation; kinetics; methylglyoxal; glyoxal; antioxidants

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Sadowska-Bartosz, I.; Galiniak, S.; Bartosz, G. Kinetics of Glycoxidation of Bovine Serum Albumin by Methylglyoxal and Glyoxal and its Prevention by Various Compounds. Molecules 2014, 19, 4880-4896.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top