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Molecules 2014, 19(4), 4595-4607;

In Vitro Antioxidant and Cytotoxic Activity of Some Synthetic Riparin-Derived Compounds

Laboratory for Research in Experimental Neurochemistry, Campus Ministro Petrônio Portella, Federal University of Piauí, Teresina, PI 64049550, Brazil
Laboratory of Bioassays for Drug Research, Federal University of Pernambuco, Recife, PE 50670-901, Brazil
Department of Chemistry, Federal Rural University of Pernambuco, Recife, PE 52171900, Brazil
Laboratory of Pharmaceutical Technology Federal University of Paraíba, João Pessoa, PB 58051-900, Brazil
Laboratory Chemistry of Bioactive Natural and Synthetic Products, Federal University of Piauí, Teresina, PI 64049550, Brazil
Department of Pharmacy, Faculty of Science and Engineering, Southern University Bangladesh, Mededibag, Chittagong-4000, Bangladesh
Author to whom correspondence should be addressed.
Received: 16 October 2013 / Revised: 17 January 2014 / Accepted: 23 January 2014 / Published: 11 April 2014
(This article belongs to the Section Medicinal Chemistry)
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This study aimed to study the in vitro antioxidant activity and cytotoxicity on tumor cells lines of six synthetic substances derived from riparins. All the substances showed antioxidant activity and riparins C, D, E, F presented cell growth inhibition rates greater than 70%, suggesting that these molecules have antitumor properties. These substances also caused greater than 80% releases of cytoplasmic lactate dehydrogenase enzyme (LDH). Although the antioxidant and antitumor properties presented herein require further assessment, the outcomes indicate that these novel riparins are promising biologically active compounds. View Full-Text
Keywords: antioxidant activity; cytotoxicity; riparins antioxidant activity; cytotoxicity; riparins

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Nunes, G.B.L.; Policarpo, P.R.; Costa, L.M.; da Silva, T.G.; Militão, G.C.G.; Câmara, C.A.; Barbosa Filho, J.M.; Gutierrez, S.J.C.; Islam, M.T.; de Freitas, R.M. In Vitro Antioxidant and Cytotoxic Activity of Some Synthetic Riparin-Derived Compounds. Molecules 2014, 19, 4595-4607.

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