Next Article in Journal
In Vitro and in Vivo Evaluation of the Antioxidant and Prooxidant Activity of Phenolic Compounds Obtained from Grape (Vitis vinifera) Pomace
Next Article in Special Issue
Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses
Previous Article in Journal
Crystallographic Studies Evidencing the High Energy Tolerance to Disrupting the Interface Disulfide Bond of Thioredoxin 1 from White Leg Shrimp Litopenaeus vannamei
Previous Article in Special Issue
Relevance of the Anti-Inflammatory Properties of Curcumin in Neurodegenerative Diseases and Depression

Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments

Institute for Maternal and Child Health—IRCCS "Burlo Garofolo"—via dell'Istria, 65/1, Trieste 34137, Italy
Department of Medicine and Surgery and Health Sciences, University of Trieste, Piazzale Europa, 1, Trieste 34137, Italy
Author to whom correspondence should be addressed.
Molecules 2014, 19(12), 21127-21153;
Received: 7 October 2014 / Revised: 8 December 2014 / Accepted: 9 December 2014 / Published: 16 December 2014
(This article belongs to the Special Issue Curcumin, Inflammation, and Chronic Diseases: How are They Linked?)
Curcumin belongs to the family of natural compounds collectively called curcuminoids and it possesses remarkable beneficial anti-oxidant, anti-inflammatory, anti-cancer, and neuroprotective properties. Moreover it is commonly assumed that curcumin has also been suggested as a remedy for digestive diseases such as inflammatory bowel diseases (IBD), a chronic immune disorder affecting the gastrointestinal tract and that can be divided in two major subgroups: Crohn’s disease (CD) and Ulcerative Colitis (UC), depending mainly on the intestine tract affected by the inflammatory events. The chronic and intermittent nature of IBD imposes, where applicable, long-term treatments conducted in most of the cases combining different types of drugs. In more severe cases and where there has been no good response to the drugs, a surgery therapy is carried out. Currently, IBD-pharmacological treatments are generally not curative and often present serious side effects; for this reason, being known the relationship between nutrition and IBD, it is worthy of interesting the study and the development of new dietary strategy. The curcumin principal mechanism is the suppression of IBD inflammatory compounds (NF-κB) modulating immune response. This review summarizes literature data of curcumin as anti-inflammatory and anti-oxidant in IBD, trying to understand the different effects in CD e UC. View Full-Text
Keywords: curcumin; inflammatory bowel disease (IBD); inflammation; innovative treatments curcumin; inflammatory bowel disease (IBD); inflammation; innovative treatments
Show Figures

Graphical abstract

MDPI and ACS Style

Vecchi Brumatti, L.; Marcuzzi, A.; Tricarico, P.M.; Zanin, V.; Girardelli, M.; Bianco, A.M. Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments. Molecules 2014, 19, 21127-21153.

AMA Style

Vecchi Brumatti L, Marcuzzi A, Tricarico PM, Zanin V, Girardelli M, Bianco AM. Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments. Molecules. 2014; 19(12):21127-21153.

Chicago/Turabian Style

Vecchi Brumatti, Liza; Marcuzzi, Annalisa; Tricarico, Paola M.; Zanin, Valentina; Girardelli, Martina; Bianco, Anna M. 2014. "Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments" Molecules 19, no. 12: 21127-21153.

Find Other Styles

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Search more from Scilit
Back to TopTop