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Open AccessReview

Anticancer Agents Targeted to Sirtuins

Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan
Faculty of Medicine, Kyoto Prefectural University of Medicine, 1-5 Shimogamohangi-Cho, Sakyo-Ku, Kyoto 606-0823, Japan
Department of Hematology and Immunology, Kagoshima University Hospital, Kagoshima, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan
Authors to whom correspondence should be addressed.
Molecules 2014, 19(12), 20295-20313;
Received: 4 October 2014 / Revised: 28 November 2014 / Accepted: 1 December 2014 / Published: 4 December 2014
Sirtuins are nicotinamide adenine dinucleotide+-dependent deacetylases of which there are seven isoforms (SIRT1–7). Sirtuin activity is linked to gene expression, lifespan extension, neurodegeneration, and age-related disorders. Numerous studies have suggested that sirtuins could be of great significance with regard to both antiaging and tumorigenesis, depending on its targets in specific signaling pathways or in specific cancers. Recent studies have identified small chemical compounds that modulate sirtuins, and these modulators have enabled a greater understanding of the biological function and molecular mechanisms of sirtuins. This review highlights the possibility of sirtuins, especially SIRT1 and SIRT2, for cancer therapy targets, and focuses on the therapeutic potential of sirtuin modulators both in cancer prevention and treatment. View Full-Text
Keywords: sirtuins; cancer; apoptosis; autophagy sirtuins; cancer; apoptosis; autophagy
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Kozako, T.; Suzuki, T.; Yoshimitsu, M.; Arima, N.; Honda, S.-I.; Soeda, S. Anticancer Agents Targeted to Sirtuins. Molecules 2014, 19, 20295-20313.

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