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Open AccessArticle

Unstable Simple Volatiles and Gas Chromatography-Tandem Mass Spectrometry Analysis of Essential Oil from the Roots Bark of Oplopanax Horridus Extracted by Supercritical Fluid Extraction

1
Department of Human Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha 410219, China
2
Department of Pharmacognosy, School of Pharmacy, Changsha Medical University, Changsha 410219, China
3
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
4
Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha 410078, China
5
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, 5841 South Maryland Avenue, MC 4028, Chicago, IL 60637, USA
*
Author to whom correspondence should be addressed.
Molecules 2014, 19(12), 19708-19717; https://doi.org/10.3390/molecules191219708
Received: 4 November 2014 / Revised: 21 November 2014 / Accepted: 24 November 2014 / Published: 27 November 2014
(This article belongs to the Section Natural Products Chemistry)
Volatile oil from the root bark of Oplopanax horridus is regarded to be responsible for the clinical uses of the title plant as a respiratory stimulant and expectorant. Therefore, a supercritical fluid extraction method was first employed to extract the volatile oil from the roots bark of O. horridus, which was subsequently analyzed by GC/MS. Forty-eight volatile compounds were identified by GC/MS analysis, including (S,E)-nerolidol (52.5%), τ-cadinol (21.6%) and S-falcarinol (3.6%). Accordingly, the volatile oil (100 g) was subjected to chromatographic separation and purification. As a result, the three compounds, (E)-nerolidol (2 g), τ-cadinol (62 mg) and S-falcarinol (21 mg), were isolated and purified from the volatile oil, the structures of which were unambiguously elucidated by detailed spectroscopic analysis including 1D- and 2D-NMR techniques. View Full-Text
Keywords: Oplopanax horridus; volatile oil; GC/MS; SFE; (S,E)-nerolidol; S-falcarinol Oplopanax horridus; volatile oil; GC/MS; SFE; (S,E)-nerolidol; S-falcarinol
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Shao, L.; Bao, M.-H.; Ouyang, D.-S.; Wang, C.-Z.; Yuan, C.-S.; Zhou, H.-H.; Huang, W.-H. Unstable Simple Volatiles and Gas Chromatography-Tandem Mass Spectrometry Analysis of Essential Oil from the Roots Bark of Oplopanax Horridus Extracted by Supercritical Fluid Extraction. Molecules 2014, 19, 19708-19717.

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