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Volume 19
Issue 11
10.3390/molecules191117078
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Review

Endocannabinoids, Related Compounds and Their Metabolic Routes

by
Filomena Fezza
1,2,*,
Monica Bari
1,
Rita Florio
3,
Emanuela Talamonti
4,5,
Monica Feole
1,2 and
Mauro Maccarrone
2,5,*
1
Department of Experimental Medicine & Surgery, Tor Vergata University of Rome, 00133 Rome, Italy
2
European Center for Brain Research/IRCCS Santa Lucia Foundation, 00143 Rome, Italy
3
Department of Movement, Human and Health Sciences, Foro Italico University of Rome, 00128 Rome, Italy
4
Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli (NA), Italy
5
Center of Integrated Research, Campus Bio-Medico University of Rome, 00135 Rome, Italy
*
Authors to whom correspondence should be addressed.
Molecules 2014, 19(11), 17078-17106; https://doi.org/10.3390/molecules191117078
Submission received: 1 August 2014 / Revised: 16 October 2014 / Accepted: 16 October 2014 / Published: 24 October 2014
(This article belongs to the Section Metabolites)
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Abstract

Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors, the primary molecular targets responsible for the pharmacological effects of the Δ9-tetrahydrocannabinol. These bioactive lipids belong mainly to two classes of compounds: N-acylethanolamines and acylesters, being N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG), respectively, their main representatives. During the last twenty years, an ever growing number of fatty acid derivatives (endocannabinoids and endocannabinoid-like compounds) have been discovered and their activities biological is the subject of intense investigations. Here, the most recent advances, from a therapeutic point of view, on endocannabinoids, related compounds, and their metabolic routes will be reviewed.
Keywords: anandamide; 2-arachidonoylglycerol; endocannabinoid metabolic routes; fatty acids anandamide; 2-arachidonoylglycerol; endocannabinoid metabolic routes; fatty acids

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MDPI and ACS Style

Fezza, F.; Bari, M.; Florio, R.; Talamonti, E.; Feole, M.; Maccarrone, M. Endocannabinoids, Related Compounds and Their Metabolic Routes. Molecules 2014, 19, 17078-17106. https://doi.org/10.3390/molecules191117078

AMA Style

Fezza F, Bari M, Florio R, Talamonti E, Feole M, Maccarrone M. Endocannabinoids, Related Compounds and Their Metabolic Routes. Molecules. 2014; 19(11):17078-17106. https://doi.org/10.3390/molecules191117078

Chicago/Turabian Style

Fezza, Filomena, Monica Bari, Rita Florio, Emanuela Talamonti, Monica Feole, and Mauro Maccarrone. 2014. "Endocannabinoids, Related Compounds and Their Metabolic Routes" Molecules 19, no. 11: 17078-17106. https://doi.org/10.3390/molecules191117078

APA Style

Fezza, F., Bari, M., Florio, R., Talamonti, E., Feole, M., & Maccarrone, M. (2014). Endocannabinoids, Related Compounds and Their Metabolic Routes. Molecules, 19(11), 17078-17106. https://doi.org/10.3390/molecules191117078

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