Next Article in Journal
State-Dependent Molecular Dynamics
Next Article in Special Issue
Impact of Trans-Resveratrol-Sulfates and -Glucuronides on Endothelial Nitric Oxide Synthase Activity, Nitric Oxide Release and Intracellular Reactive Oxygen Species
Previous Article in Journal
Studies Regarding As(V) Adsorption from Underground Water by Fe-XAD8-DEHPA Impregnated Resin. Equilibrium Sorption and Fixed-Bed Column Tests
Previous Article in Special Issue
New Water-Soluble Carbamate Ester Derivatives of Resveratrol
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessReview
Molecules 2014, 19(10), 16102-16121;

Resveratrol and Endothelial Nitric Oxide

Department of Pharmacology, Johannes Gutenberg University Medical Center, Obere Zahlbacher Str. 67, Mainz 55131, Germany
Author to whom correspondence should be addressed.
Received: 18 August 2014 / Revised: 21 September 2014 / Accepted: 25 September 2014 / Published: 9 October 2014
(This article belongs to the Special Issue Resveratrol)
Full-Text   |   PDF [959 KB, uploaded 9 October 2014]   |  


Nitric oxide (NO) derived from the endothelial NO synthase (eNOS) has antihypertensive, antithrombotic, anti-atherosclerotic and antiobesogenic properties. Resveratrol is a polyphenol phytoalexin with multiple cardiovascular and metabolic effects. Part of the beneficial effects of resveratrol are mediated by eNOS. Resveratrol stimulates NO production from eNOS by a number of mechanisms, including upregulation of eNOS expression, stimulation of eNOS enzymatic activity and reversal of eNOS uncoupling. In addition, by reducing oxidative stress, resveratrol prevents oxidative NO inactivation by superoxide thereby enhancing NO bioavailability. Molecular pathways underlying these effects of resveratrol involve SIRT1, AMPK, Nrf2 and estrogen receptors. View Full-Text
Keywords: resveratrol; nitric oxide; eNOS; SIRT1; Nrf2 resveratrol; nitric oxide; eNOS; SIRT1; Nrf2

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Xia, N.; Förstermann, U.; Li, H. Resveratrol and Endothelial Nitric Oxide. Molecules 2014, 19, 16102-16121.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top