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Resveratrol and Endothelial Nitric Oxide

Department of Pharmacology, Johannes Gutenberg University Medical Center, Obere Zahlbacher Str. 67, Mainz 55131, Germany
Author to whom correspondence should be addressed.
Molecules 2014, 19(10), 16102-16121;
Received: 18 August 2014 / Revised: 21 September 2014 / Accepted: 25 September 2014 / Published: 9 October 2014
(This article belongs to the Special Issue Resveratrol)
Nitric oxide (NO) derived from the endothelial NO synthase (eNOS) has antihypertensive, antithrombotic, anti-atherosclerotic and antiobesogenic properties. Resveratrol is a polyphenol phytoalexin with multiple cardiovascular and metabolic effects. Part of the beneficial effects of resveratrol are mediated by eNOS. Resveratrol stimulates NO production from eNOS by a number of mechanisms, including upregulation of eNOS expression, stimulation of eNOS enzymatic activity and reversal of eNOS uncoupling. In addition, by reducing oxidative stress, resveratrol prevents oxidative NO inactivation by superoxide thereby enhancing NO bioavailability. Molecular pathways underlying these effects of resveratrol involve SIRT1, AMPK, Nrf2 and estrogen receptors. View Full-Text
Keywords: resveratrol; nitric oxide; eNOS; SIRT1; Nrf2 resveratrol; nitric oxide; eNOS; SIRT1; Nrf2
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MDPI and ACS Style

Xia, N.; Förstermann, U.; Li, H. Resveratrol and Endothelial Nitric Oxide. Molecules 2014, 19, 16102-16121.

AMA Style

Xia N, Förstermann U, Li H. Resveratrol and Endothelial Nitric Oxide. Molecules. 2014; 19(10):16102-16121.

Chicago/Turabian Style

Xia, Ning, Ulrich Förstermann, and Huige Li. 2014. "Resveratrol and Endothelial Nitric Oxide" Molecules 19, no. 10: 16102-16121.

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