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Molecules 2014, 19(10), 15440-15451;

A New Isoflavonoid from Seeds of Lepidium sativum L. and Its Protective Effect on Hepatotoxicity Induced by Paracetamol in Male Rats

Department of Chemistry, Faculty of Science, Tanta University, Tanta 31527, Egypt
Department of Chemistry and Biochemistry, Faculty of Science, Tabuk University, Tabuk P.O. Box 699, Tabuk 71491, Saudi Arabia
Faculty of Specific Education, Zagazig University, Zagazig 44519, Egypt
Department of Basic and Clinical Medical Science, Faculty of Dentistry, P. Qaseem University, Qaseem 51411, Saudi Arabia
Department of Home Economics, Faculty of Specific Education, Kafr ElSheikh University, Kafr ElSheikh 33516, Egypt
Author to whom correspondence should be addressed.
Received: 2 July 2014 / Revised: 30 July 2014 / Accepted: 26 August 2014 / Published: 26 September 2014
(This article belongs to the Section Medicinal Chemistry)
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A new isoflavonoid, 5,6-dimethoxy-2',3'-methylenedioxy-7-C-β-d-gluco-pyranosyl isoflavone was isolated from the seeds of Lepidium sativum L. along with two known isoflavonoids, 7-hydroxy-4',5,6-trimethoxyisoflavone and 7-hydroxy-5,6-dimethoxy-2',3'-methylenedioxyisoflavone. The structures of all compounds were elucidated with NMR spectrometry. Compounds 1, 2 and the new isoflavonoid 3 were evaluated for their ability to reduce the hepatotoxicity induced by paracetamol in male rats by reducing the damage and toxicity effects on liver cells with a significant improvement of total antioxidant capacity, normalizing the levels of liver enzymes GSH, SOD, GPX, CAT and GST compared to control group. View Full-Text
Keywords: Lepidium sativum; isoflavonoid; hepatotoxicity Lepidium sativum; isoflavonoid; hepatotoxicity

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Sakran, M.; Selim, Y.; Zidan, N. A New Isoflavonoid from Seeds of Lepidium sativum L. and Its Protective Effect on Hepatotoxicity Induced by Paracetamol in Male Rats. Molecules 2014, 19, 15440-15451.

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