Next Article in Journal
Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines
Previous Article in Journal
Acetylcholinesterase Inhibitory, Antioxidant and Phytochemical Properties of Selected Medicinal Plants of the Lamiaceae Family
Article Menu

Export Article

Open AccessCommunication
Molecules 2014, 19(1), 783-794;

Preventive Effects of Citrus unshiu Peel Extracts on Bone and Lipid Metabolism in OVX Rats

Functionality Evaluation Research Group, Division of Metabolism and Functionality Research, Korea Food Research Institute, Seongnam 463-746, Korea
Department of Bio & Fermentation Convergence Technology, Kookmin University, Seoul 136-702, Korea
Author to whom correspondence should be addressed.
Received: 18 November 2013 / Revised: 6 January 2014 / Accepted: 7 January 2014 / Published: 9 January 2014
(This article belongs to the Section Natural Products Chemistry)
Full-Text   |   PDF [700 KB, uploaded 18 June 2014]   |  


Dried Citrus unshiu peel has been widely used for various medicinal purposes in Oriental Medicine. This study evaluated the metabolic effects of dried C. unshiu peel in ovariectomized (OVX) rats. The OVX rats were divided into five groups treated with distilled water, 17β-estradiol (E2 10 μg/kg, once daily, i.p.) and dried C. unshiu peel extracts (DCPE 30, 100 and 300 mg/kg, once daily, p.o.) for eight weeks. The treatments with high-dose DCPE significantly decreased the bone mineral density (BMD) loss in the femur, which was reflected by the decrease in alkaline phosphatase (ALP), telopeptides of collagen type I (CTx) and osteocalcin (OC) serum levels. It also inhibited the increase in lipoprotein levels compared to the OVX-control group without elevating the serum levels of estradiol, aspartate aminotransferase (AST) and alanine transaminase (ALT). Furthermore, DCPE exhibits a hepatoprotective effect in OVX-induced hepatic steatosis, indicated by reduced hepatic lipid contents. Taken together, our findings suggest that DCPE has the potential to improve both lipid and bone metabolism without influencing hormones such as estrogen in OVX rats. View Full-Text
Keywords: Citrus unshiu peel; anti osteoporosis; hepatoprotective effect Citrus unshiu peel; anti osteoporosis; hepatoprotective effect

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Lim, D.W.; Lee, Y.; Kim, Y.T. Preventive Effects of Citrus unshiu Peel Extracts on Bone and Lipid Metabolism in OVX Rats. Molecules 2014, 19, 783-794.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top