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In Situ Formation of Steroidal Supramolecular Gels Designed for Drug Release

Modulation of Xenobiotic Receptors by Steroids

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
Author to whom correspondence should be addressed.
Molecules 2013, 18(7), 7389-7406;
Received: 24 May 2013 / Revised: 13 June 2013 / Accepted: 19 June 2013 / Published: 24 June 2013
(This article belongs to the Special Issue Steroids)
Nuclear receptors (NRs) are ligand-activated transcription factors that regulate the expression of their target genes. NRs play important roles in many human diseases, including metabolic diseases and cancer, and are therefore a key class of therapeutic targets. Steroids play important roles in regulating nuclear receptors; in addition to being ligands of steroid receptors, steroids (and their metabolites) also regulate other NRs, such as the pregnane X receptor and constitutive androstane receptor (termed xenobiotic receptors), which participate in steroid metabolism. Xenobiotic receptors have promiscuous ligand-binding properties, and their structurally diverse ligands include steroids and their metabolites. Therefore, steroids, their metabolism and metabolites, xenobiotic receptors, steroid receptors, and the respective signaling pathways they regulate have functional interactions. This review discusses these functional interactions and their implications for activities mediated by steroid receptors and xenobiotic receptors, focusing on steroids that modulate pathways involving the pregnane X receptor and constitutive androstane receptor. The emphasis of the review is on structure-function studies of xenobiotic receptors bound to steroid ligands. View Full-Text
Keywords: nuclear receptors; pregnane X receptor: constitutive androstane receptor; steroid nuclear receptors; pregnane X receptor: constitutive androstane receptor; steroid
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MDPI and ACS Style

Banerjee, M.; Robbins, D.; Chen, T. Modulation of Xenobiotic Receptors by Steroids. Molecules 2013, 18, 7389-7406.

AMA Style

Banerjee M, Robbins D, Chen T. Modulation of Xenobiotic Receptors by Steroids. Molecules. 2013; 18(7):7389-7406.

Chicago/Turabian Style

Banerjee, Monimoy, Delira Robbins, and Taosheng Chen. 2013. "Modulation of Xenobiotic Receptors by Steroids" Molecules 18, no. 7: 7389-7406.

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