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Molecular Mechanism Underlying Anti-Inflammatory and Anti-Allergic Activities of Phytochemicals: An Update

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Laboratory of Research on Local Animal Products, Ibn-Khaldoun University of Tiaret, Tiaret 14000, Algeria
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Faculty of Nature and Life Sciences, Abderrahmane Mira University, Béjaia 06000, Algeria
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Mohammad Hussein Al Amoudi Chair for Diabetic Foot Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia
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Department of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia
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Department of Nutrition Food Sciences, Arts and Design College, King Abdulaziz University, Jeddah 21589, Saudi Arabia
*
Author to whom correspondence should be addressed.
Molecules 2013, 18(1), 322-353; https://doi.org/10.3390/molecules18010322
Received: 13 September 2012 / Revised: 6 December 2012 / Accepted: 14 December 2012 / Published: 27 December 2012
(This article belongs to the Section Natural Products Chemistry)
The resort worldwide to edible medicinal plants for medical care has increased significantly during the last few years. Currently, there is a renewed interest in the search for new phytochemicals that could be developed as useful anti-inflammatory and anti-allergic agents to reduce the risk of many diseases. The activation of nuclear transcription factor-kappa B (NF-κB) has now been linked to a variety of inflammatory diseases, while data from numerous studies underline the importance of phytochemicals in inhibiting the pathway that activates this transcription factor. Moreover, the incidence of type I allergic disorders has been increasing worldwide, particularly, the hypersensitivity to food. Thus, a good number of plant products with anti-inflammatory and anti-allergic activity have been documented, but very few of these compounds have reached clinical use and there is scant scientific evidence that could explain their mode of action. Therefore, this paper intends to review the most salient recent reports on the anti-inflammatory and anti-allergic properties of phytochemicals and the molecular mechanisms underlying these properties. View Full-Text
Keywords: phytochemicals; anti-inflammatory; anti-allergic; molecular mechanisms phytochemicals; anti-inflammatory; anti-allergic; molecular mechanisms
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MDPI and ACS Style

Bellik, Y.; Boukraâ, L.; Alzahrani, H.A.; Bakhotmah, B.A.; Abdellah, F.; Hammoudi, S.M.; Iguer-Ouada, M. Molecular Mechanism Underlying Anti-Inflammatory and Anti-Allergic Activities of Phytochemicals: An Update. Molecules 2013, 18, 322-353.

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