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Open AccessArticle

Cytotoxic and Antioxidant Compoundsfrom the Stem Bark of Goniothalamus tapisoides Mat Salleh

1
Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
2
Faculty of Applied Sciences, MARA University of Technology, 40450 Shah Alam, Selangor, Malaysia
3
Department of Pharmacy, University of Malaya, 50603 Kuala Lumpur, Malaysia
4
Institute of Biological Sciences, Faculty of Sciences Building, University of Malaya, 50603 Kuala Lumpur, Malaysia
5
Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia
*
Author to whom correspondence should be addressed.
Molecules 2013, 18(1), 128-139; https://doi.org/10.3390/molecules18010128
Received: 8 November 2012 / Revised: 16 December 2012 / Accepted: 19 December 2012 / Published: 21 December 2012
Eleven compounds:goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 µM. View Full-Text
Keywords: Goniothalamus tapisoides; goniomicins A–D; tapisoidin; cytotoxicity; antioxidant activity Goniothalamus tapisoides; goniomicins A–D; tapisoidin; cytotoxicity; antioxidant activity
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Kim, R.P.T.; Bihud, V.; Bin Mohamad, K.; Leong, K.H.; Bin Mohamad, J.; Bin Ahmad, F.; Hazni, H.; Kasim, N.; Halim, S.N.A.; Awang, K. Cytotoxic and Antioxidant Compoundsfrom the Stem Bark of Goniothalamus tapisoides Mat Salleh. Molecules 2013, 18, 128-139.

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