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Open AccessArticle

Phylattrin, a New Cytotoxic Xanthone from Calophyllum soulattri

1
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
2
Faculty of Medicine and Health Science, Universiti Tunku Abdul Rahman, 43000 Kajang, Selangor, Malaysia
3
Department of Biology, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
*
Author to whom correspondence should be addressed.
Molecules 2012, 17(7), 8303-8311; https://doi.org/10.3390/molecules17078303
Received: 30 May 2012 / Revised: 27 June 2012 / Accepted: 28 June 2012 / Published: 10 July 2012
(This article belongs to the Section Natural Products Chemistry)
Our continuing studies on secondary metabolites from the stem bark of Calophyllum soulattri has led to the isolation of another new diprenylated xanthone, phylattrin (1), in addition to five other xanthones and two common sterols. The xanthones are soulattrin (2), caloxanthone C (3), macluraxanthone (4), brasixanthone B (5) and trapezifolixanthone (6) while the sterols are stigmasterol (7) and β-sitosterol (8). The structures of these compounds were determined on the basis of spectroscopic analyses such as 1D and 2D-NMR, HRESIMS, IR and UV. Compounds 17 exhibited moderate cytotoxic activities against SNU-1, HeLa, Hep G2, NCI-H23, K562, Raji, LS174T, IMR-32 and SK-MEL-28 cells. View Full-Text
Keywords: Calophyllum soulattri; Clusiaceae; cytotoxic; phylattrin; xanthone Calophyllum soulattri; Clusiaceae; cytotoxic; phylattrin; xanthone
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Mah, S.H.; Ee, G.C.L.; Teh, S.S.; Rahmani, M.; Lim, Y.M.; Go, R. Phylattrin, a New Cytotoxic Xanthone from Calophyllum soulattri. Molecules 2012, 17, 8303-8311.

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