Ginsenoside Rb1 Attenuates Intestinal Ischemia Reperfusion Induced Renal Injury by Activating Nrf2/ARE Pathway
Abstract
:1. Introduction
2. Results and Discussion
2.1. Effects of Ginsenoside Rb1 on Renal Functional Injury Induced by IIR
Sham | IIR | NS | Rb1-30 | Rb1-60 | |
---|---|---|---|---|---|
BUN | 9.37 ± 1.19 | 21.55 ± 1.50 * | 18.87 ± 2.16 * | 15.52 ± 1.23 # | 12.91 ± 1.41 # |
Cr | 10.26 ± 1.25 | 20.65 ± 1.53 * | 19.53 ± 1.19 * | 16.00 ± 1.50 # | 13.14 ± 1.22 # |
NAGL | 71.65 ± 4.65 | 155.93 ± 8.07 * | 150.11 ± 6.09 * | 124.44 ± 6.52 # | 101.76 ± 12.20 # |
2.2. Effects of Ginsenoside Rb1 on SOD and MDA Levels in Renal Tissues
2.3. Effects of Ginsenoside Rb1 on HO-1 and Nrf2 Expressions in Renal Tissues by Immunohisto- Chemical Analysis
2.4. Effects of Ginsenoside Rb1 on HO-1 and Nrf2 Expressions in Renal Tissues by Western Blot Analysis
2.5. Renal Histopathological Assessment
3. Experimental
3.1. Materials
3.2. Experimental Protocol
3.3. Measurement of Serum BUN, Cr and NGAL
3.4. Renal Tissues SOD and MDA Assay
3.5. Renal HO-1 and Nrf2 Immunohistochemical Assays
3.6. Renal Tissues HO-1 and Nrf2 Western Blot Analysis
3.7. Renal Histopathological Assessment
3.8. Statistical Analysis
4. Conclusions
Acknowledgements
Conflict of Interest
- Sample Availability: Not available.
Reference and Notes
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Sun, Q.; Meng, Q.-T.; Jiang, Y.; Xia, Z.-Y. Ginsenoside Rb1 Attenuates Intestinal Ischemia Reperfusion Induced Renal Injury by Activating Nrf2/ARE Pathway. Molecules 2012, 17, 7195-7205. https://doi.org/10.3390/molecules17067195
Sun Q, Meng Q-T, Jiang Y, Xia Z-Y. Ginsenoside Rb1 Attenuates Intestinal Ischemia Reperfusion Induced Renal Injury by Activating Nrf2/ARE Pathway. Molecules. 2012; 17(6):7195-7205. https://doi.org/10.3390/molecules17067195
Chicago/Turabian StyleSun, Qian, Qing-Tao Meng, Ying Jiang, and Zhong-Yuan Xia. 2012. "Ginsenoside Rb1 Attenuates Intestinal Ischemia Reperfusion Induced Renal Injury by Activating Nrf2/ARE Pathway" Molecules 17, no. 6: 7195-7205. https://doi.org/10.3390/molecules17067195