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Molecules 2012, 17(5), 5924-5934;

Scope and Limitations of a Novel Synthesis of 3-Arylazonicotinates

Chemistry Department, Faculty of Science at Qena, South Valley University, P.O. Box 83523, Qena, Egypt
Department of Chemistry, Faculty of Science, University of Kuwait, P.O. Box 5969, Safat 13060, Kuwait
Authors to whom correspondence should be addressed.
Received: 27 January 2012 / Revised: 13 May 2012 / Accepted: 15 May 2012 / Published: 18 May 2012
(This article belongs to the Special Issue Heterocycles)
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The reaction of 3-oxo-3-phenyl-2-phenylhydrazonal with functionally substituted and heteroaromatic substituted acetonitrile to yield arylazonicotinic acid derivatives and 5-arylsubstituted pyridines was established. In some cases the produced nicotinates could not be isolated as they underwent thermally induced 6π-electrocyclization yielding polynuclear pyridine derivatives. View Full-Text
Keywords: 3-oxo-3-phenyl-2-phenylhydrazonal; arylazonicotinic acid; pyridine; electrocyclization; heteroaromatics 3-oxo-3-phenyl-2-phenylhydrazonal; arylazonicotinic acid; pyridine; electrocyclization; heteroaromatics

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Zaky, O.S.; Moustafa, M.S.; Selim, M.A.; El-Maghraby, A.M.; Elnagdi, M.H. Scope and Limitations of a Novel Synthesis of 3-Arylazonicotinates. Molecules 2012, 17, 5924-5934.

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