Next Article in Journal
Tropical Plant Extracts as Potential Antihyperglycemic Agents
Next Article in Special Issue
Palladium-Catalyzed Amination of Dichloroquinolines with Adamantane-Containing Amines
Previous Article in Journal
Synthesis of 1,2,3-Triazole Derivatives and in Vitro Antifungal Evaluation on Candida Strains
Previous Article in Special Issue
Drug Resistance Modulation in Staphylococcus Aureus, a New Biological Activity for Mesoionic Hydrochloride Compounds
Article Menu

Export Article

Open AccessReview
Molecules 2012, 17(5), 5893-5914;

Modifications on the Basic Skeletons of Vinblastine and Vincristine

Department of Organic Chemistry and Technology, University of Technology and Economics, H-1111 Budapest, Szt. Gellért tér 4, Hungary
Author to whom correspondence should be addressed.
Received: 30 March 2012 / Revised: 9 May 2012 / Accepted: 10 May 2012 / Published: 18 May 2012
(This article belongs to the Special Issue Advances in Heteroaromatic Chemistry)


The synthetic investigation of biologically active natural compounds serves two main purposes: (i) the total synthesis of alkaloids and their analogues; (ii) modification of the structures for producing more selective, more effective, or less toxic derivatives. In the chemistry of dimeric Vinca alkaloids enormous efforts have been directed towards synthesizing new derivatives of the antitumor agents vinblastine and vincristine so as to obtain novel compounds with improved therapeutic properties. View Full-Text
Keywords: antitumor therapy; vinblastine; vincristine; derivatives antitumor therapy; vinblastine; vincristine; derivatives

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Keglevich, P.; Hazai, L.; Kalaus, G.; Szántay, C. Modifications on the Basic Skeletons of Vinblastine and Vincristine. Molecules 2012, 17, 5893-5914.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top