Next Article in Journal
Synthesis of a 2,2'-Bipyridyl Functionalized Oligovinylene-Phenylene Using Heck and Horner-Wadsworth-Emmons Reactions and X-ray Crystal Structure of E-(4-(4-Bromostyryl)phenyl)(methyl)sulfane
Previous Article in Journal
QSAR Modeling on Benzo[c]phenanthridine Analogues as Topoisomerase I Inhibitors and Anti-cancer Agents
Article Menu

Export Article

Open AccessArticle
Molecules 2012, 17(5), 5713-5723; https://doi.org/10.3390/molecules17055713

Antifungal Activities of New Coumarins

1
Chemical Engineering Faculty, University of Kabengassan Malaysia (UKM), Selangor 43000, Malaysia
2
Applied Chemistry division, Applied Science Department, University of Technology UOT), Baghdad 10066, Iraq
*
Author to whom correspondence should be addressed.
Received: 31 March 2012 / Revised: 12 April 2012 / Accepted: 20 April 2012 / Published: 14 May 2012
(This article belongs to the Section Medicinal Chemistry)
Full-Text   |   PDF [1086 KB, uploaded 18 June 2014]   |  

Abstract

Newly synthesized coumarins 4-((5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)-methoxy)-2H-chromen-2-one and 4-((5-(phenylamino)-1,3,4-thiadiazol-2-yl)-methoxy)-2H-chromen-2-one were tested against selected types of fungi and showed significant activities. DFT calculations of the synthesized coumarins were performed using molecular structures with optimized geometries. Molecular orbital calculations provide a detailed description of the orbitals, including spatial characteristics, nodal patterns, and the contributions of individual atoms. View Full-Text
Keywords: antifungal; 4-aminoantipyrine; benzyl bromide; coumarins; DFT; ethyl bromoacetate; 4-hydroxycoumarin antifungal; 4-aminoantipyrine; benzyl bromide; coumarins; DFT; ethyl bromoacetate; 4-hydroxycoumarin
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Al-Amiery, A.A.; Kadhum, A.A.H.; Mohamad, A.B. Antifungal Activities of New Coumarins. Molecules 2012, 17, 5713-5723.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top