Next Article in Journal
Repeated Dose 28-Days Oral Toxicity Study of Carica papaya L. Leaf Extract in Sprague Dawley Rats
Previous Article in Journal
Organocatalysis in Synthesis: L-Proline as an Enantioselective Catalyst in the Synthesis of Pyrans and Thiopyrans
Article Menu

Export Article

Open AccessCommunication
Molecules 2012, 17(4), 4313-4325;

New Methodology for the Synthesis of Thiobarbiturates Mediated by Manganese(III) Acetate

Laboratoire de Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Institut de Chimie Radicalaire ICR, UMR 7273, Aix-Marseille Univ, CNRS, 27 Bd Jean Moulin, CS 30064, 13385 Marseille Cedex 05, France
Author to whom correspondence should be addressed.
Received: 15 March 2012 / Revised: 30 March 2012 / Accepted: 31 March 2012 / Published: 10 April 2012
Full-Text   |   PDF [231 KB, uploaded 18 June 2014]   |  


A three step synthesis of various thiobarbiturate derivatives 1724 was established. The first step is mediated by Mn(OAc)3, in order to generate a carbon-carbon bond between a terminal alkene and malonate. Derivatives 18 were obtained in moderate to good yields under mild conditions. This key step allows synthesis of a wide variety of lipophilic thiobarbiturates, which could be tested for their anticonvulsive or anesthesic potential. View Full-Text
Keywords: manganese(III) acetate; barbiturates; radical manganese(III) acetate; barbiturates; radical

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Bouhlel, A.; Curti, C.; Vanelle, P. New Methodology for the Synthesis of Thiobarbiturates Mediated by Manganese(III) Acetate. Molecules 2012, 17, 4313-4325.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top