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Molecules 2012, 17(2), 1890-1899;

A New Class of Heterocycles: 1,4,3,5-Oxathiadiazepane 4,4-dioxides

Laboratoire de Chimie Organique Appliquée, Groupe de chimie Hétérocyclique, Département de Chimie, Faculté des Sciences, Université d’Annaba, BP 12, 23000, Algérie
Laboratoire de Chimie des Matériaux Organiques, Université de Tébessa, Route de Constantine, Tébessa, 12000, Algérie
Author to whom correspondence should be addressed.
Received: 19 January 2012 / Revised: 6 February 2012 / Accepted: 8 February 2012 / Published: 14 February 2012
(This article belongs to the Special Issue Heterocycles)
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This work reports the synthesis of novel 1,4,3,5-oxathiadiazepanes 4,4-dioxides from the reaction of N’-benzyl-N-(2-hydroxyethyl)-sarcosine or proline sulfamide with aromatic aldehydes under acid catalysis. To prepare the starting materials N-Boc-sulfamide derivatives of sarcosine or proline were alkylated with benzyl alcohol under Mitsunobu reaction conditions, the Boc group was removed chemoselectively by acidolysis, and the resulting product reduced to the corresponding alcohol in good yields. View Full-Text
Keywords: cyclic sulfamides; benzodithiazine dioxides; benzoxathiazepine dioxides cyclic sulfamides; benzodithiazine dioxides; benzoxathiazepine dioxides

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Bendjeddou, A.; Abbaz, T.; Regainia, Z.; Aouf, N.-E. A New Class of Heterocycles: 1,4,3,5-Oxathiadiazepane 4,4-dioxides. Molecules 2012, 17, 1890-1899.

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