Next Article in Journal
In Vitro Antifungal Activity of Sanguinarine and Chelerythrine Derivatives against Phytopathogenic Fungi
Next Article in Special Issue
Anti-Infectious Agents against MRSA
Previous Article in Journal
Quercetin Improves Baroreflex Sensitivity in Spontaneously Hypertensive Rats
Previous Article in Special Issue
Synthetic Flavanones Augment the Anticancer Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
Open AccessReview

Action of Natural Products on P2 Receptors: A Reinvented Era for Drug Discovery

Laboratory of Cellular Communication, Oswaldo Cruz Foundation, 4365 Rio de Janeiro, Brazil
Laboratory of Immnopharmacology, Oswaldo Cruz Foundation, 4365 Rio de Janeiro, Brazil
Author to whom correspondence should be addressed.
Molecules 2012, 17(11), 13009-13025;
Received: 7 September 2012 / Revised: 12 October 2012 / Accepted: 24 October 2012 / Published: 1 November 2012
(This article belongs to the Collection Bioactive Compounds)
Natural products contribute significantly to available drug therapies and have been a rich source for scientific investigation. In general, due to their low cost and traditional use in some cultures, they are an object of growing interest as alternatives to synthetic drugs. With several diseases such as cancer, and inflammatory and neuropathic diseases having been linked to the participation of purinergic (P2) receptors, there has been a flurry of investigations on ligands within natural products. Thirty-four different sources of these compounds have been found so far, that have shown either agonistic or antagonistic effects on P2 receptors. Of those, nine different plant sources demonstrated effects on P2X2, P2X3, P2X7, and possibly P2Y12 receptor subtypes. Microorganisms, which represent the largest group, with 26 different sources, showed effects on both receptor subtypes, ranging from P2X1 to P2X4 and P2X7, and P2Y1, P2Y2, P2Y4, and P2Y6. In addition, there were seventeen animal sources that affected P2X7 and P2Y1 and P2Y12 receptors. Natural products have provided some fascinating new mechanisms and sources to better understand the P2 receptor antagonism. Moreover, current investigations should clarify further pharmacological mechanisms in order to consider these products as potential new medicines. View Full-Text
Keywords: P2 receptors; natural products; antagonists P2 receptors; natural products; antagonists
MDPI and ACS Style

Faria, R.; Ferreira, L.; Bezerra, R.; Frutuoso, V.; Alves, L. Action of Natural Products on P2 Receptors: A Reinvented Era for Drug Discovery. Molecules 2012, 17, 13009-13025.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Search more from Scilit
Back to TopTop