Next Article in Journal
Synergistic Antibacterial Activity of the Essential Oil of Aguaribay (Schinus molle L.)
Previous Article in Journal
Synthesis and Antiplasmodial Activity of Betulinic Acid and Ursolic Acid Analogues
Article Menu

Export Article

Open AccessArticle
Molecules 2012, 17(10), 12015-12022;

Nukuhivensiums, Indolo[2,3-a]quinoliziniums from the Marquesan Plant Rauvolfia nukuhivensis

Laboratory UMR 241 EIO, University of French Polynesia, 98702 Faa'a, Tahiti, French Polynesia
Laboratory UMR 7245 CNRS, National Museum of Natural History, 63 rue Buffon, 75005 Paris, France
Nice Institute of Chemistry UMR 7272 CNRS-PCRE, University of Nice-Sophia Antipolis, Parc Valrose, 06108 Nice, France
Authors to whom correspondence should be addressed.
Received: 13 September 2012 / Revised: 7 October 2012 / Accepted: 9 October 2012 / Published: 12 October 2012
(This article belongs to the Section Natural Products Chemistry)
PDF [364 KB, uploaded 18 June 2014]


The first phytochemical inspection of the Marquesan endemic plant Rauvolfia nukuhivensis led to the isolation and structure characterization of two new indolo[2,3‑a]quinolizinium derivatives named nukuhivensium (1) and N12-methyl-nukuhivensium (2). They feature an aromatic indolo[2,3-a]quinolizinium core, substituted at C-2 by a n-propyl group, which is unusual in this family of alkaloid derivatives. The structure elucidation was performed on the basis of NMR spectroscopy and especially by interpretation of 2D HMBC correlations. A biosynthetic pathway is proposed on the basis of known enzymatic transformations for this family of natural products. These compounds exhibited low antimicrobial activities. View Full-Text
Keywords: alkaloid; Rauvolfia; antimicrobial; indoles; biosynthesis alkaloid; Rauvolfia; antimicrobial; indoles; biosynthesis

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Martin, N.J.; Prado, S.; Lecellier, G.; Thomas, O.P.; Raharivelomanana, P. Nukuhivensiums, Indolo[2,3-a]quinoliziniums from the Marquesan Plant Rauvolfia nukuhivensis. Molecules 2012, 17, 12015-12022.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top